Original Title: Eficacia y efectividad de la capnografía transcutánea en pacientes con enfermedad respiratoria obstructiva crónica con hipercapnia en atención primaria

Authors' objectives: The objectives are to evaluate the efficacy and effectiveness of CTC as an alternative to arterial blood gases in the identification of Chronic Obstructive Pulmonary Disease patients with hypercapnia in primary care, and its applicability prior to or during treatment with oxygen therapy in primary care.

Authors' results and conclusions: RESULTS: The preliminary literature search allowed identify 1,002 publications (246 in Medline, 561 in EMBASE, and 195 in the Cochrane Library) on CTC in chronic lung disease. Once duplicates were excluded (n=294), due to title and abstract (n=698), and for other reasons (n=10), 4 original articles were finally included that evaluated the concordance of the PCO2 measurement between blood gases and the CTC. The selected studies present evidence of low quality and high risk of bias, especially in the selection of patients and the applicability of the index test, according to the QUADAS-2 criteria. No evidence was found of the use of this technique in primary care setting. Transcutaneous measurements underestimate arterial PaCO2 values and have very wide limits of agreement, and the dispersion of the measurement increases in patients with moderate or severe hypercapnia. CONCLUSIONS: No evidence has been found to assess the efficacy and effectiveness of CTC compared with arterial blood gases as a diagnostic method for hypercapnia in patients with Chronic Obstructive Pulmonary Disease.

Authors' methods: A systematic review (SR) of the available scientific literature on the efficacy and effectiveness of CTC in patients with chronic respiratory disease was performed. A specific search strategy was designed to locate studies up to November 2022. Two reviewers independently selected the studies by reading the titles and abstracts retrieved from the literature search, extracted data from the included studies, and assessed the quality of the studies using the QUADAS-2 tool. Evidence tables were developed from the data extraction forms. The participation of interest groups was also collected: patients, clinicians and industry.

Project Status: Completed

Year Published: 2024

URL for published report: https://repisalud.isciii.es/rest/api/core/bitstreams/f70e6873-2c00-465a-acaa-e5cbac41fe50/content

URL for additional information: https://redets.sanidad.gob.es/productos/buscarProductos.do?metodo=detalle&id=1247

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: Spain

Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias

Contact Address: Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;

Contact Name: Esther E. García Carpintero

Contact Email: eegarcia@isciii.es

Copyright: Agencia de Evaluacion de Tecnologias Sanitarias