[Contrast-enhanced mammography in the diagnostic process of breast cancer]

de Tomás Mateo E, García Mur C, Moler Zapata S, Vicente Edo MJ, Martín Sánchez JI
Record ID 32018015611
Spanish
Original Title: Mamografía con contraste en el proceso diagnóstico de cáncer de mama
Authors' objectives: The objective of this report is to evaluate the scientific evidence on efficacy/effectiveness, safety, economic aspects, as well as women’s values and preferences, environmental, legal, and ethical aspects of CEM in the breast cancer diagnostic process compared to the usual technology in use in the following scenarios: • Diagnostic scenario 1: Women with dense breasts. • Diagnostic scenarios 2 and 3: Women with inconclusive findings or with clinical or diagnostic suspicion of breast cancer. • Diagnostic scenario 4: Women with breast cancer undergoing follow-up after NAT. • Diagnostic scenario 5: Women at intermediate and high risk of breast cancer undergoing diagnosis.
Authors' results and conclusions: The evidence compiled in this report suggests that CEM technology shows similar diagnostic performance to other imaging techniques (MG, ECO or CE-MRI), with mild and temporary associated adverse effects. Furthermore, it is a tool that is well accepted by patients and could be a cost-effective option as a complementary technique to MG in some cases. However, the current evidence is insufficient to replace other established imaging techniques across the board. In turn, CEM involves higher doses of radiation, which raises clinical, ethical and environmental concerns, especially in the absence of conclusive benefits. Future high-quality research could be key to determining in which clinical contexts CEM can significantly improve the management of breast cancer, taking into account the need for fully informed consent.
Details
Project Status: Completed
Year Published: 2026
URL for published report: https://www.iacs.es/wp-content/uploads/2026/05/I80_IACS_Mamografia-contraste_DEF_NIPO.pdf
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Spain
DOI: https://doi.org/10.46994/ets_50
MeSH Terms
  • Breast Neoplasms
  • Mammography
  • Contrast Media
  • Radiographic Image Enhancement
Keywords
  • “contrast-enhanced mammography”
  • “contrast-enhanced spectral mammography”
  • “enhanced spectral mammography”
  • “contrast-enhanced digital mammography”
  • “contrast-enhanced dual-energy mammography”
  • “dual-energy contrast enhanced digital mammography”
  • Senobright
  • “Selenia Dimensions”
Contact
Organisation Name: Health Sciences Institute in Aragon (IACS)
Contact Address: Avda, San Juan Bosco, 13, planta 2
Contact Name: María Pilar Alfonso Palacín
Contact Email: palfonso.iacs@aragon.es
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.