Original Title: Biomarqueurs tumoraux liés à la prise en charge des personnes atteintes d’un cancer de la thyroïde de stade avancé

Authors' objectives: Next-generation sequencing (NGS) is a more recent method that provides gene panel based analysis of different combinations of target sequences in a variety of genes associated with several pathological conditions, including cancer. As such, NGS has the potential to replace several laboratory analyses, which are currently performed independently. With the aim of promoting the judicious use of this type of analysis and to standardize patient care, INESSS has been mandated by the Direction de la cancérologie (DC) to compile a list of useful biomarkers to guide the management of people with various types of solid tumors, including advanced thyroid cancer (TC).

Authors' results and conclusions: RESULTS: A total of 20 publications were selected regarding tumor biomarkers recommended for the management of advanced thyroid cancer or solid tumors aimed by agnostic therapy (indirectly including CT). The biomarkers recommended in the selected publications are predictive and include various types of alterations in the BRAF genes (mainly V600 mutations), RET and NTRK, high microsatellite instability (MSI-H), mismatch repair defects (dMMR), and high tumor mutational burden (TMB-H). CONCLUSION: There are some tumor biomarkers associated with the management of individuals with advanced thyroid cancer. Only one biomarker (RET – rearranged during transfection) is associated with a treatment available in Quebec, while others are related to drugs approved for other indications, not yet evaluated, or whose application for approval has been refused for the relevant indications

Authors' methods: Evidence supporting recommendations from cited organizations was extracted from published primary studies to document the magnitude of benefit derived from the decision to personalize management according to the biomarker detected.

Project Status: Completed

Year Published: 2026

URL for published report: https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Oncologie/Biomarqueurs_Thyroide_EC_INESSS.pdf

English language abstract: An English language summary is available

Publication Type: Other

Country: Canada

Province: Quebec

Organisation Name: Institut national d'excellence en sante et en services sociaux

Contact Address: L'Institut national d'excellence en sante et en services sociaux (INESSS) , 2021, avenue Union, bureau 10.083, Montreal, Quebec, Canada, H3A 2S9;Tel: 1+514-873-2563, Fax: 1+514-873-1369

Contact Name: demande@inesss.qc.ca

Contact Email: demande@inesss.qc.ca

Copyright: L'Institut national d'excellence en sante et en services sociaux (INESSS)