Original Title: Ablación percutánea guiada por tomografía computarizada de las neoplasias de pulmón primarias y metastásicas mediante radiofrecuencia o microondas en pacientes no susceptibles de terapia local curativa y/o sistemática

Authors' objectives: To analyse the efficacy, effectiveness, safety and economic, organisational, ethical, and legal implications of the use and utility of CT-guided percutaneous ablation of lung metastasis using radiofrequency ablation (RFA) and microwave ablation (MWA) in patients who are not eligible for curative local and/or systemic treatment.

Authors' results and conclusions: After the removal of duplicates, the literature search identified 163 potentially relevant articles. On first screening, 103 were rejected for not meeting our selection criteria. After reading the title and abstract, 33 were selected for full-text reading, and finally, 3 were included. From the ECRI reports, 9 studies were included, and from the alerts set, a further 10 studies were selected for the synthesis of the evidence. Of the total of 22 studies, 12 were systematic reviews and meta-analyses, 9 trials and 1 cost-analysis. Ablation techniques are recommended in patients who are not eligible for surgery, but larger randomised studies are needed to confirm that this is a reliable alternative, given that, provided the stage of the disease allows, surgery remains the treatment of choice. We consider it necessary to prospectively compare ablation techniques with other well-established techniques for the treatment of lung cancer, alone or in combination, by conducting monitoring studies.

Authors' methods: Based on two reports from ECRI Institute, and to bring the list of studies cited therein up to date, a literature search was conducted in medical databases including the following terms as free text and controlled vocabulary: lung neoplasms, microwave ablation and radiofrequency ablation. A pair of researchers independently screened articles retrieved, selected those considered relevant, appraised the full text of these articles and then, by applying the selection criteria, classified them as included or excluded from the subsequent analysis.

Project Status: Completed

Year Published: 2024

URL for published report: https://www.euskadi.eus/contenidos/informacion/osteba_publicacion/eu_def/adjuntos/E-25-01-Ablacion_percutanea_guiada_tomografia.pdf

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: Spain

Organisation Name: Basque Office for Health Technology Assessment

Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz

Contact Name: Lorea Galnares-Cordero

Contact Email: lgalnares@bioef.eus

Copyright: <p>Osteba (Basque Office for Health Technology Assessment) Health Department of the Basque Government</p>