Arthrosamid® in treating knee osteoarthritis (OA)
WorkSafeBC Evidence-Based Practice Group, Martin CW
Record ID 32018014879
English
Authors' objectives:
To determine whether there is any evidence to support the efficacy/effectiveness of Arthrosamid® in treating knee osteoarthritis (OA) and if there is any evidence on its efficacy/effectiveness, at what stage of knee osteoarthritis that Arthrosamid® is the most effective.
Authors' results and conclusions:
Eleven published reports were identified and one further report was identified from manual searches. Overall, there were twelve published reports identified on this systematic review. Of the twelve reports that were identified, seven reports were thought to be relevant and were retrieved in full for further appraisal. It should be noted that all these seven reports were still published in an abstract only format with limited availability of information especially regarding the methodology section of the paper which is important in assessing the validity. Of the seven papers, five papers came from data of only one study reported at one , two and three years follow-up. It should further be noted that the same dataset (on three years follow-up) was presented by same authors in two different publications. Hence only one publication of this dataset will be presented further. One study reported the one-year outcome on the effectiveness of one intra-articular injection of polyacrylamide hydrogel (Arthrosamid®) with one injection of hyaluronic acid (Synvisc-One®) in patients with knee osteoarthritis (OA) from three clinic sites in Denmark with 239 randomized participants. The authors stated that there was a clinically relevant decrease in WOMAC pain subscale score from baseline to 26 weeks in both groups and concluded that the analysis of the change from baseline to week 26 demonstrated noninferiority, with a treatment difference of 3.6 (95% CI: -0.9 - 8.1) in favor of Arthrosamid® compared to hyaluronic acid. The same authors reported the two year follow-up from the same study summarized above. However, from the 119 (out of 239) participants originally recruited in the Arthrosamid® group it is unclear the number reported at the one year follow-up, data from only 32 patients were reported in this two-year follow-up study . It should be noted that the authors did not provide any information on the characteristics of those reported in the two-year follow-up and those lost to follow-up; hence selection bias is a strong possibility. At present, there are some, high-level low quality as well as from low level-low quality, evidence on the efficacy/effectiveness of Arthrosamid® in treating knee OA. However, given the nature of the evidence presented currently, these observations need to be interpreted with caution since the role of bias, chance and confounding in affecting the reported outcome cannot be ruled out. Our systematic literature search identified three randomized controlled trial studies that were registered at Clinicaltrials.Gov since 2019 and no data/outcome has been reported. These clinical trials will be followed up for updating this systematic review in the future.
Authors' methods:
A comprehensive and systematic literature search was conducted on July 4, 2025. The search was done on commercial medical literature databases using a combination of keywords. No limitations, such as on the language or year of publication, were implemented in any of these searches. A manual search was also conducted on the references of articles that were retrieved in full.
Details
Project Status:
Completed
URL for project:
https://www.worksafebc.com/en/about-us/research-services/evidence-based-medicine-and-systematic-reviews
Year Published:
2025
English language abstract:
An English language summary is available
Publication Type:
Mini HTA
Country:
Canada
MeSH Terms
- Osteoarthritis, Knee
- Osteoarthritis
- Injections, Intra-Articular
- Acrylic Resins
Keywords
- Arthrosamid
- intra-articular polyacrylamide hydrogel injection
- knee osteoarthritis
Contact
Organisation Name:
WorkSafeBC
Contact Address:
6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698
Contact Name:
ebpg@worksafebc.com
Contact Email:
ebpg@worksafebc.com
Copyright:
WorkSafe BC
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.