Authors' objectives: To determine whether there is any evidence on the efficacy/effectiveness of platelet-rich plasma in treating Sinus Tarsi Syndrome.

Authors' results and conclusions: Two published studies were identified from the above search. Upon examination of the titles and abstracts of these two studies, one study was thought to be relevant and was retrieved in full for further appraisal. No further relevant studies were identified from manual search. In a small (n total 56) randomized controlled trial (level of evidence 1) Toy et al reported the application of corticosteroid and local anesthetic (CLA), platelet-rich plasma (PRP) and ozone injections on patients diagnosed with sinus tarsi syndrome where conservative treatments (NSAIDs, physiotherapy and local gels) failed for three months and had no previous injections treatments. Initially, the study recruited 60 patients and divided these 60 patients equally into three treatment groups. However, four patients (two each in PRP and Ozone groups) were loss due to low-up, hence only the results of the 56 patients were reported at the end of the study (six months follow-up). On the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS) measurement, the authors reported that there was significant improvement in all three groups throughout the study period. However, at the end of months 1 and 3, the AOFAS score improvement was significantly in favor of the CLA group; while at the end of the study, there was no significant differences among the three groups regarding their AOFAS score. The authors concluded that Ozone, CLA, or PRP injections could provide clinically significant improvement for at least six months in patients with sinus tarsi syndrome. However, this conclusion has to be interpreted with caution. It should be noted that it was not clear how patients were recruited, what the primary outcome was, and what time frame the follow-up was associated with the supposed sample size calculation. At present, there is some high level evidence of very low quality, where bias, chance and confounding cannot be excluded, regarding the effectiveness of PRP in treating Sinus Tarsi Syndrome.

Authors' methods: A systematic literature search was started on July 8, 2024 conducted on commercial medical literature databases. The search was done by employing combinations of keywords. No other limitations were implemented in any of these searches. A manual search was also planned and conducted on the references of the articles that were retrieved in full.

Project Status: Completed

URL for project: https://www.worksafebc.com/en/about-us/research-services/evidence-based-medicine-and-systematic-reviews

Year Published: 2024

URL for published report: https://www.worksafebc.com/en/resources/health-care-providers/guides/efficacy-effectiveness-platelet-rich-plasma-treating-sinus-tarsi-syndrome?lang=en&origin=s&returnurl=https%3A%2F%2Fwww.worksafebc.com%2Fen%2Fforms-resources%23sort%3DDate%26q%3DEfficacy%252FEffectiveness%2520of%2520Platelet%2520Rich%2520Plasma%2520in%2520Treating%2520Sinus%2520Tarsi%2520Syndrome%26f%3Alanguage-facet%3D%5BEnglish%5D%26tags%3DGuide%7C2d7eb4b30f6a4a319e0d40565c9abbab%2CHealth%2520Care%2520Provider%7C13468b0b3f074f6bade3f57ac3cdfb8e%2CSystematic%2520Review%7Cf78c29d570c14ec3b5a394385905df70&highlight=Efficacy/Effectiveness%20of%20Platelet%20Rich%20Plasma%20in%20Treating%20Sinus%20Tarsi%20Syndrome

English language abstract: An English language summary is available

Publication Type: Mini HTA

Country: Canada

Organisation Name: WorkSafeBC

Contact Address: 6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698

Contact Name: ebpg@worksafebc.com

Contact Email: ebpg@worksafebc.com

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