One-stage matrix-assisted cartilage repair with and without bone marrow aspirate concentrate in the knee
Riegelnegg M, Pleyer J, Goetz G
Record ID 32018014479
English
Authors' objectives:
Cartilage defects in the knee may cause pain, swelling, and reduce quality of life. One-stage matrix-assisted cartilage repair (AMIC- autologous matrix-induced chondrogenesis) combines microfracture with a collagen matrix, while AMIC+ additionally incorporates bone marrow aspirate concentrate.
Authors' results and conclusions:
Ten studies with 786 patients were included (8 RCTs, 2 NRCTs). Evidence (moderate to very low certainty) indicates that AMIC provides better structural repair compared to microfracture, with comparable or improved functional outcomes and a similar or better safety profile. For AMIC+, superiority over standard therapies could not be established due to the limited evidence base. Key limitations include lack of blinding and insufficient data on long-term effectiveness beyond 24 months.
Details
Project Status:
Completed
Year Published:
2025
URL for published report:
https://eprints.aihta.at/1567/1/DSD_146.pdf
URL for additional information:
https://eprints.aihta.at/1567/
English language abstract:
An English language summary is available
Publication Type:
Full HTA
Country:
Austria
MeSH Terms
- Chondrogenesis
- Collagen
- Hyaluronan Synthases
- Tissue Scaffolds
- Bone Marrow
- Transplantation, Autologous
- Extracellular Matrix
- Knee
- Cartilage
- Knee Injuries
Keywords
- Cartilage defects
- one-stage matrix-assisted cartilage repair
- microfracture
- bone marrow aspirate concentrate
Contact
Organisation Name:
Austrian Institute for Health Technology Assessment
Contact Address:
Josefstaedter Strasse 39, A-1080 Vienna, Austria
Contact Name:
office@aihta.at
Contact Email:
office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.