Islet cell transplantation for chronic pancreatitis, type 1 diabetes, with and without kidney transplantation

Hollyoak R, Hofer V, Nicolopoulos K, Cameron A
Record ID 32018014476
English
Authors' objectives: Islet cell transplantation (ICT) involves isolating islet cells from either the patient's pancreas (autologous, for chronic pancreatitis) or donor pancreas (allogenic, for type 1 diabetes). Following portal vein infusion, these cells resume insulin production. In CP patients, ICT typically complements pancreatectomy to replace functional tissue. For type 1 diabetics, ICT provides an alternative to ongoing insulin therapy and may be performed alongside kidney transplantation.
Authors' results and conclusions: One RCT, three NRCTs, and eight single-arm case series were included. Evidence of very low certainty indicates an additional benefit for patients with type 1 diabetes and kidney transplantation. No additional benefit was demonstrated for the other two indications—chronic pancreatitis and type 1 diabetes without kidney transplantation. The overall certainty of evidence remains very low due to methodological shortcomings, and RCTs are lacking for the assessment of patient-relevant outcomes in all assessed populations.
Authors' recommendations: Re-evaluation should be undertaken as soon as data from further randomised controlled trials become available.
Details
Project Status: Completed
URL for project: https://aihta.at/page/bewertung-medizinischer-einzelleistungen-mel-berichte/en
Year Published: 2025
URL for published report: https://eprints.aihta.at/1564/1/DSD_143.pdf
URL for additional information: https://eprints.aihta.at/1564/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Glycemic Control
  • Cell Transplantation
  • Pancreatitis, Chronic
  • Diabetes Mellitus, Type 1
  • Kidney Transplantation
  • Islets of Langerhans
  • Islets of Langerhans Transplantation
  • Insulin
  • Hypoglycemia
Keywords
  • Islet cell transplantation
  • chronic pancreatitis
  • type 1 diabetes
  • blood glucose control
  • insulin
Contact
Organisation Name: Austrian Institute for Health Technology Assessment
Contact Address: Josefstaedter Strasse 39, A-1080 Vienna, Austria
Contact Name: office@aihta.at
Contact Email: office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.