Extracorporeal carbon dioxide removal for the treatment of acute hypoxaemic respiratory failure: the REST RCT
McNamee JJ, Agus A, Boyle AJ, Jackson C, McDowell C, Haglund J, McAuley DF
Record ID 32018014428
English
Authors' objectives:
In patients who require mechanical ventilation for acute hypoxaemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. To determine whether using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxaemic respiratory failure and is cost-effective.
Authors' results and conclusions:
The trial was stopped early because of futility and feasibility. The 90-day mortality rate was 41.5% in the extracorporeal carbon dioxide removal group versus 39.5% in the standard care group (risk ratio 1.05, 95% confidence interval 0.83 to 1.33; difference 2.0%, 95% confidence interval − 7.6% to 11.5%; p = 0.68). There were significantly fewer mean ventilator-free days in the extracorporeal carbon dioxide removal group compared with the standard care group (7.1, 95% confidence interval 5.9 to 8.3) versus (9.2, 95% confidence interval 7.9 to 10.4) days; mean difference, −2.1 (95% confidence interval −3.8 to −0.3; p = 0.02). Serious adverse events were reported for 62 patients (31%) in extracorporeal carbon dioxide removal group and 18 (9%) in the standard care group, including intracranial haemorrhage in 9 patients (4.5%) versus 0 (0%) and bleeding at other sites in 6 (3.0%) versus 1 (0.5%) in the extracorporeal carbon dioxide removal group versus the control group. Two-year mortality data were available for 95% of patients. There was no difference in the time to death between groups (hazard ratio 1.08, 95% confidence interval 0.81 to 1.44; log-rank test p = 0.61). There was no difference in long-term outcomes between groups. There was no difference in quality-adjusted life-years at 12 months (mean difference −0.01, 95% confidence interval −0.06 to 0.05). Total 12-month costs were statistically significantly higher in the extracorporeal carbon dioxide removal group (mean difference £7668.76, 95% confidence interval £159.75 to £15,177.77). Secondary analyses indicated there may be heterogeneity of treatment effect based on physiological characteristics of the patients. A systematic review supported these findings. There were no short- or long-term benefits found, and the device was associated with higher cost and potentially significant complications. We would advise against using this device in addition to standard care for the treatment of patients with hypoxaemic respiratory failure, outside of future clinical trials.
Authors' methods:
A multicentre, randomised, allocation-concealed, open-label, pragmatic clinical trial. Fifty-one intensive care units across the United Kingdom. Four hundred and twelve adult patients receiving mechanical ventilation for acute hypoxaemic respiratory failure, of a planned sample size of 1120. Lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal for at least 48 hours (n = 202) or standard care with conventional low tidal volume ventilation (n = 210). All-cause mortality 90 days. Secondary outcomes included ventilator-free days; adverse events; extracorporeal membrane oxygenation use; long-term mortality; health-related quality of life; health service costs; long-term respiratory morbidity. Only 6% of screened patients were included in the study; most sites were naive to the intervention before the study commenced; other aspects of care were not standardised in each group, because this was a pragmatic trial; the trial may have been underpowered to detect a clinically important difference, because the trial was stopped early; blinding to the clinicians or patients was not possible.
Details
Project Status:
Completed
URL for project:
https://www.journalslibrary.nihr.ac.uk/programmes/hta/NIHR135678
Year Published:
2025
URL for published report:
https://www.journalslibrary.nihr.ac.uk/hta/published-articles/GJDM0320
URL for additional information:
English
English language abstract:
An English language summary is available
Publication Type:
Full HTA
Country:
England, United Kingdom
DOI:
10.3310/GJDM0320
MeSH Terms
- Hypoxia
- Respiratory Insufficiency
- Respiration, Artificial
- Extracorporeal Membrane Oxygenation
- Carbon Dioxide
- Intensive Care Units
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
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