[Tumor biomarkers related to the management of people with breast cancer]
Roy, MC
Record ID 32018014368
French
Original Title:
Biomarqueurs tumoraux liés à la prise en charge des personnes atteintes d’un cancer du sein
Authors' objectives:
Next-generation sequencing (NGS) is a more recent method that provides gene panelbased analysis of different combinations of target sequences in a variety of genes
associated with several pathological conditions, including cancer. With the aim of promoting the judicious use of this type of analysis and to standardize
patient care, INESSS has been mandated by the Direction cancérologie (DC) to compile
a list of useful biomarkers to guide the management of people with various types of solid
tumors, including breast cancer.
Authors' results and conclusions:
RESULTS: A total of 53 publications were selected. Biomarkers recommended by expert
panels/professional organizations are mostly predictive and include the expression of
estrogen receptor, HER2 and PD- L1, various types of alterations in PIK3CA, AKT1,
PTEN, ESR1, BRCA1/2, PALB2, HER2, NTRK and RET genes, high microsatellite
instability (MSI-H), mismatch repair defects (dMMR) and high tumor mutational load
(TMB-H). Progesterone receptors and Ki-67 are two biomarkers identified with a
prognostic value only. CONCLUSION: There are several tumor biomarkers associated with the management of individuals with
breast cancer. Some are currently used in the context of Quebec practice, while others
are associated with drugs that are either not approved or approved for other indications in
Canada, or which have been refused listing for the indication under consideration.
According to the experts consulted, information provided by biomarker testing would be
useful for the management of people with breast cancer, as it contributes to a better
characterization of the disease and enables a certain number of patients to benefit from
various drug access programs or to be directed towards the appropriate clinical studies.
To find clinical trials underway in Quebec, readers are invited to consult the Registre
public des essais cliniques du Québec.
Authors' methods:
An exhaustive literature review (practice guidelines and expert consensus) was
conducted to identify tumor biomarkers recommended for the management of breast
cancer or solid tumors targeted by an agnostic therapeutic approach (indirectly including
breast cancer).
Evidence supporting recommendations from cited organizations was extracted from
published primary studies to document the magnitude of benefit derived from the decision
to personalize management according to the biomarker detected.
Information pertaining to approval and listing status of drugs associated with predictive
biomarkers was collected to determine the value of testing for these biomarkers in the
current context of Quebec practice.
Details
Project Status:
Completed
Year Published:
2025
URL for published report:
https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Oncologie/Biomarqueur_Cancer_sein_EC_INESSS.pdf
English language abstract:
An English language summary is available
Publication Type:
Other
Country:
Canada
Province:
Quebec
MeSH Terms
- Breast Neoplasms
- Biomarkers, Tumor
- Disease Management
- Biomarkers
- Precision Medicine
Contact
Organisation Name:
Institut national d'excellence en sante et en services sociaux
Contact Address:
L'Institut national d'excellence en sante et en services sociaux (INESSS) , 2021, avenue Union, bureau 10.083, Montreal, Quebec, Canada, H3A 2S9;Tel: 1+514-873-2563, Fax: 1+514-873-1369
Contact Name:
demande@inesss.qc.ca
Contact Email:
demande@inesss.qc.ca
Copyright:
L'Institut national d'excellence en sante et en services sociaux (INESSS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.