[Methods for the quantification of direct-acting oral anticoagulants in plasma]
Pérez García G, Urcola Pardo F, Pereira Iglesias A, Isern de Val MS
Record ID 32018014264
Spanish
Original Title:
Técnicas de laboratorio para la cuantificación de anticoagulantes orales de acción directa en plasma
Authors' objectives:
To analyse and synthesise the available scientific evidence on the analytical accuracy, clinical utility, safety and efficiency of plasma DOAC quantification methods.
Authors' results and conclusions:
Evidence suggests that quantification of dabigatran by ecarin-based methods and rivaroxaban by chromogenic anti-Xa assays is accurate. However, the low confidence in the results does not allow extrapolation and generalisation of the findings to our context. Apixaban quantification has not been
shown to have adequate accuracy. DOAC quantification tests are useful for decision making by clinicians, but so far it has not been demonstrated that these decisions are leading to better clinical outcomes in patients or to a lower use of resources and costs.
Authors' methods:
Systematic review of the scientific evidence on the efficacy or effectiveness, safety and efficiency of methods of quantifying plasma concentrations of DOAC in patients receiving DOAC for the prevention or treatment of thromboembolic diseases. The search period covered January 2012 to March 2024. Publications in English, French or Spanish were selected. Controlled clinical trials with or without randomisation and observational studies without comparison group with sample size greater than 30 people were included. Study selection was conducted in duplicate.
Study quality was assessed with the QUADAS-2 tool for studies of diagnostic accuracy and FLC 3.0 for all other studies. In the case of more than one study reporting sensitivity and specificity variables, meta-analysis of the results was performed. The Youden index of the methods was calculated
to facilitate comparison of diagnostic performance. GRADE synthesis was performed for diagnostic accuracy results and qualitative synthesis for the remaining results.
Details
Project Status:
Completed
Year Published:
2024
URL for published report:
https://www.iacs.es/wp-content/uploads/2025/05/I40_IACS_ACOD_DEF_NIPO.pdf
English language abstract:
An English language summary is available
Publication Type:
Mini HTA
Country:
Spain
MeSH Terms
- Anticoagulants
- Atrial Fibrillation
- Venous Thromboembolism
- Embolism and Thrombosis
- Drug Monitoring
- Factor Xa Inhibitors
- Dabigatran
- Rivaroxaban
- Thrombin Time
Contact
Organisation Name:
Health Sciences Institute in Aragon (IACS)
Contact Address:
Avda, San Juan Bosco, 13, planta 2
Contact Name:
María Pilar Calvo Pérez
Contact Email:
direccion.iacs@aragon.es
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.