Original Title: Seguridad y eficacia del uso de prendas de compresión en el tratamiento del lipedema

Authors' objectives: The aim of this health technology assessment report is to evaluate the safety and efficacy of the use of compression garments in people with lipedema who perform physical exercise and hygienic dietary measures.

Authors' results and conclusions: RESULTS: The search in all the databases consulted retrieved 282 references after eliminating duplicates. In the analysis by titles and abstracts, 54 potentially relevant articles were selected for detailed full-text analysis. Five of these articles could not be obtained and are pending evaluation. After applying the pre-established selection criteria to the remaining 49, none could be included. Only 3 studies were identified that, although they did not meet the established selection criteria, could be of interest. Nor were any studies located that are yet to be published or are in progress that exactly answered the question posed for this report. CONCLUSIONS: No available scientific evidence is identified on the additional benefit of using compression garments, along with standard care (physical exercise and hygienic-dietary measures), in the treatment of lipedema in the lower or upper limbs compared to usual care alone.

Authors' methods: A systematic review of the published scientific literature was carried out by consulting the following biomedical databases: MEDLINE, Embase, CENTRAL and CINAHL (search date: April 1, 2024). The comprehensive search strategy developed included controlled vocabulary and free terms. In addition, a search for studies was carried out in two World Health Organization resources: the databases available in the Biblioteca Virtual en Salud and the International Clinical Trials Registry to consult ongoing studies. We selected studies published in English, Spanish or French that evaluated, in people of any age and sex with a diagnosis of lipedema, the efficacy and safety of the use of compression garments on upper or lower limbs in combination with treatment or usual care (physical exercise and hygienic-dietary measures) compared to treatment or usual care alone. In the study design story, only randomized clinical trials were selected. Failing that, non-randomized clinical trials and, failing that, observational studies with a control group. The selection of studies and the extraction of information and assessment of the risk of bias of the included studies was planned to be carried out in duplicate by two reviewers. To assess the risk of bias of the randomized clinical trials, we considered using the RoB-2 tool. The evaluation of the quality of evidence was planned to be performed according to the GRADE system.

Project Status: Completed

Year Published: 2024

URL for published report: https://sescs.es/en/safety-efficacy-compression-garments-lipedema/

English language abstract: An English language summary is available

Publication Type: Full HTA

Country: Spain

Organisation Name: Canary Health Service

Contact Address: Dirección del Servicio. Servicio Canario de la Salud, Camino Candelaria 44, 1ª planta, 38109 El Rosario, Santa Cruz de Tenerife

Contact Name: sescs@sescs.es

Contact Email: sescs@sescs.es