Human growth hormone for Turner's syndrome

Alberta Heritage Foundation for Medical Research
Record ID 31998008932
Authors' objectives: This report is in response to the request from the Province Wide Services Advisory Committee for information regarding the effectiveness of human growth hormone in patients with Turner's syndrome. This report will summarize the efficacy of recombinant growth hormone (GH) in improving height in girls with Turner's syndrome. Included is a brief introduction on Turner's, a historical perspective on the use of GH and data on the natural growth pattern in this condition. Also included is a synopsis of guidelines from the American Academy of Pediatrics and the Lawson Wilkins Pediatric Endocrine Society, a review of clinical trials and a summary of recognized adverse events.
Authors' recommendations: The results from studies reported thus far are very suggestive of the efficacy of GH in girls with Turner's syndrome. The determinants of growth in these individuals are complex, with GH playing only one part. It is clear that some girls respond very well to GH therapy, while others do not. The short term side effects of GH therapy are well established and amenable to monitoring and therapy. There is no data at this time regarding the long term sequelae of GH therapy in these individuals. The issues that appear to be important regarding the use of GH in these girls are: 1. Use of adequate doses (0.3 mg/kg/week). 2. Delaying the introduction of estrogen therapy until a bone age of 13-14 years. 3. Considering the use of anabolic steroids when growth velocity begins to wane on GH alone. 4. Uncertainty regarding the optimum age to start therapy. 5. Uncertainty regarding long term side effects.
Authors' methods: Review
Project Status: Completed
Year Published: 1998
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Body Height
  • Child
  • Estrogens
  • Turner Syndrome
Organisation Name: Institute of Health Economics
Contact Address: 1200, 10405 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3N4. Tel: +1 780 448 4881; Fax: +1 780 448 0018;
Contact Name:
Contact Email:
Copyright: Alberta Heritage Foundation for Medical Research
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.