Efficacy/effectiveness of nSTRIDE injection in treating patients with knee osteoarthritis
WorkSafeBC Evidence-Based Practice Group, Martin CW
Record ID 32018013677
English
Authors' objectives:
To determine whether there is any evidence on the efficacy/effectiveness of nSTRIDE® injection in treating patient with knee osteoarthritis (OA).
Authors' results and conclusions:
Thirty published studies were identified from the literature search. Upon examination on the titles and abstracts of these 30 studies, 19 studies were thought to be relevant and were retrieved in full for further appraisal. Of these 19 studies, 10 studies were in the form of expert or systematic reviews, were traced of their relevant primary studies and are not discussed further. Of the 19 that were retrieved in full, seven studies provided relevant data were appraised and summarized. At present, there is some biological plausibility, through the work on cytokines (as opposed to platelets in PRP preparation), on the potential role of APS in treating (knee) OA. At present, there are some low-level, in the form of five small case series and one high level, small RCT all low-quality evidence on the efficacy/effectiveness of nSTRIDE® APS in treating patients with knee OA. It should be strongly noted that the potential for bias, chance and effect of confounding cannot be excluded from affecting the reported outcomes on these studies. At present, there are some temporary adverse events including joint effusion and arthralgia reported in these studies.
Authors' methods:
A comprehensive and systematic literature search was conducted on June 12, 2024. The search was done on commercial medical literature databases. A combination of keywords were employed in this search. No limitation, such as on the language and date of publication was employed in this search. A manual search was done on the references of the articles that were retrieved in full. Relevant primary studies will be identified and retrieved from the identified expert or systematic reviews and the review articles will not be employed further.
Details
Project Status:
Completed
URL for project:
https://www.worksafebc.com/en/about-us/research-services/evidence-based-medicine-and-systematic-reviews
Year Published:
2024
English language abstract:
An English language summary is available
Publication Type:
Mini HTA
Country:
Canada
MeSH Terms
- Osteoarthritis, Knee
- Injections, Intra-Articular
- Knee Joint
- Pain
Keywords
- nSTRIDE
- APS
- injection
- autologous
- protein
- solution
- knee
- osteoarthritis
Contact
Organisation Name:
WorkSafeBC
Contact Address:
6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698
Contact Name:
ebpg@worksafebc.com
Contact Email:
ebpg@worksafebc.com
Copyright:
WorkSafe BC
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.