Authors' objectives:

Research has examined the effect of low literacy on a wide variety of health outcomes, but we are unaware of any published systematic reviews that have analyzed these relationships or examined interventions to mitigate the health effects of low literacy. To evaluate the existing research, we performed a systematic review to address two four-part key questions based on questions initially posed by the American Medical Association and the Agency for Healthcare Research and Quality and put into final form in cooperation with our Technical Expert Advisory Group. The questions are as follows:

-Key Question 1: Are literacy skills related to: (a) Use of health care services? (b) Health outcomes? (c) Costs of health care? (d) Disparities in health outcomes or health care service use according to race, ethnicity, culture, or age?

-Key Question 2: For individuals with low literacy skills, what are effective interventions to: (a) Improve use of health care services? (b) Improve health outcomes? (c) Affect the costs of health care? (d) Improve health outcomes and/or health care service use among different racial, ethnic, cultural, or age groups?

Authors' results and conclusions: We identified 3,015 unique abstracts from our literature searches. We excluded 2,330 that clearly did not meet our inclusion criteria after abstract review. Of the 684 remaining articles subjected to full review, 611 were rejected and 73 retained. Of those retained, 44 articles addressed KQ 1 and 29 articles addressed KQ 2. Studies examining the relationship between low literacy and adverse health outcomes generally found that patients with low literacy had poorer health outcomes, including knowledge, intermediate disease markers, measures of morbidity, general health status, and use of health resources. Most studies were cross-sectional in design, and many failed to adequately address confounding and the use of multiple comparisons in their analyses. For KQ 2, most interventions led to improved outcomes, particularly for outcomes of understanding or knowledge. Fewer studies examined the effect of interventions for patients with low health literacy on morbidity and mortality. Based on our 11-item quality scale, we found that the average quality of the individual articles addressing KQs 1a and 1b was good to fair. The quality of the one article addressing KQ 2a was good; the average quality of the articles addressing KQ 2b was fair. We did not find literature that discussed the portion of the key questions addressing costs or disparities, so an average grade is not available. We also graded the strength of the evidence for this body of literature on a scale from I (strongest design) to IV (no published literature). We concluded that the literature addressing KQ 1a and 1b should receive a grade of II; it generally includes studies of strong design, but some uncertainty remains because of concerns about generalizability, bias, research design flaws, and adequate sample size. The literature addressing KQ 1c and 1d was rated III since the evidence is from a limited number of studies of weaker design and studies with strong designs have not been done. The literature addressing KQ 2a and 2b also received a grade of III, while the literature addressing KQ 2c and 2d received a grade of IV, indicating that there was no published literature.

Authors' recommendations: Low literacy is associated with several adverse health outcomes, including low health knowledge, increased incidence of chronic illness, poorer intermediate disease markers, and less than optimal use of preventive health services. Interventions to mitigate the effects of low literacy have been studied, and some have shown promise for improving patient health and receipt of health care services. Future research, using more rigorous methods, is required to better define these relationships and to guide development of new interventions.

Authors' methods: Systematic review

Project Status: Completed

URL for project: http://www.ahrq.gov/clinic/tp/littp.htm

Year Published: 2004

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: United States

Organisation Name: Agency for Healthcare Research and Quality

Contact Address: Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;

Contact Name: martin.erlichman@ahrq.hhs.gov

Contact Email: martin.erlichman@ahrq.hhs.gov

Copyright: Agency for Healthcare Research and Quality (AHRQ)