Efficacy/effectiveness of orexin antagonists in treating insomnia associated with TBI

WorkSafeBC Evidence-Based Practice Group, Martin CW
Record ID 32018013215
English
Authors' objectives: To determine whether there is there any evidence on the efficacy/effectiveness of orexin antagonists class of drugs in treating insomnia associated with traumatic brain injury.
Authors' results and conclusions: Thirteen published studies were identified. Upon examination on the titles and abstracts of these 13 studies, six studies were thought to be relevant and were retrieved in full for further appraisal. None of the six studies retrieved in full provided data on the application of orexin antagonists drug class in treating insomnia post traumatic brain injury. At present, there is no study reporting the efficacy/effectiveness of orexin antagonist drug class to treat insomnia among patients diagnosed with traumatic brain injury.
Authors' methods: A comprehensive and systematic literature search was conducted on February 26, 2024. The search was done on commercial and non-commercial medical literature databases. A combination of keywords was employed on this search. No limitation, such as on the language or date of publication, was implemented in this search. A manual search was also done on the references of the articles that were retrieved in full.
Details
Project Status: Completed
URL for project: https://www.worksafebc.com/en/about-us/research-services/evidence-based-medicine-and-systematic-reviews
Year Published: 2024
URL for published report: https://www.worksafebc.com/en/resources/health-care-providers/guides/efficacy-effectiveness-orexin-antagonists-treating-insomnia-associated-with-tbi?lang=en&origin=s&returnurl=https%3A%2F%2Fwww.worksafebc.com%2Fen%2Fforms-resources%23sort%3DDate%26q%3DEfficacy%252FEffectiveness%2520of%2520Orexin%2520Antagonists%2520in%2520Treating%2520Insomnia%2520Associated%2520with%2520TBI%26f%3Alanguage-facet%3D%5BEnglish%5D%26tags%3DGuide%7C2d7eb4b30f6a4a319e0d40565c9abbab%2CHealth%2520Care%2520Provider%7C13468b0b3f074f6bade3f57ac3cdfb8e%2CSystematic%2520Review%7Cf78c29d570c14ec3b5a394385905df70&highlight=Efficacy/Effectiveness%20of%20Orexin%20Antagonists%20in%20Treating%20Insomnia%20Associated%20with%20TBI
English language abstract: An English language summary is available
Publication Type: Mini HTA
Country: Canada
MeSH Terms
  • Brain Injuries, Traumatic
  • Sleep Initiation and Maintenance Disorders
  • Orexin Receptor Antagonists
  • Brain Concussion
Keywords
  • Orexin antagonists
  • orexin receptor antagonists
  • suvorexant
  • Lemborexant
  • daridorexant
  • insomnia
  • sleep disturbance
  • traumatic brain injury
Contact
Organisation Name: WorkSafeBC
Contact Address: 6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698
Contact Name: ebpg@worksafebc.com
Contact Email: ebpg@worksafebc.com
Copyright: WorkSafe BC
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.