Stem cell transplantation

Alberta Heritage Foundation for Medical Research
Record ID 31998008925
Authors' objectives: This report has been produced in response to a request for information on whether stem cell transplantation is similar to bone marrow transplantation, whether stem cell transplantation is experimental and if its application should be expanded.
Authors' recommendations: Autologous peripheral stem cell transplantation (APSCT) and autologous bone marrow transplantation (ABMT) are technologies with a similar purpose, provision of stem cells to counter effects of bone marrow suppression. Evidence from published studies demonstrate that ABMT and APSCT are similar in terms of early post-transplant morbidity and mortality, relapse-free survival rate, time to treatment failure and overall survival. APSCT is no longer an experimental technology, though its use in some indications has not yet been validated. Current practice trends suggest that APSCT will be preferred to ABMT as follow-up to high-dose chemotherapy, and it is likely that there will be expansion of its application.
Authors' methods: Review
Project Status: Completed
Year Published: 1997
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Antineoplastic Agents
  • Bone Marrow Transplantation
  • Chemotherapy, Adjuvant
  • Hematopoietic Stem Cell Transplantation
Organisation Name: Institute of Health Economics
Contact Address: 1200, 10405 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3N4. Tel: +1 780 448 4881; Fax: +1 780 448 0018;
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Copyright: Alberta Heritage Foundation for Medical Research
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.