Hyperbaric oxygen therapy for central osteoradionecrosis

Patterson J
Record ID 32004000054
Authors' objectives:

This study aims to assess the effects of hyperbaric oxygen therapy for treating or preventing osteoradionecrosis, in people who have previously received radiotherapy.

Authors' recommendations: The first RCT, examining effects of hyperbaric oxygen therapy for established mandibular osteoradionecrosis, is likely to lack reliability.The second RCT provided limited evidence that hyperbaric oxygen therapy may help to prevent mandibular osteoradionecrosis compared with penicillin in people undergoing tooth extractions, who had previously received oral radiotherapy. However, this conclusion remains tentative in the absence of further trials. Neither trial reported on harms of treatment and we found no trials of therapy in osteoradionecrosis of other parts of the body.
Authors' methods: Review
Project Status: Completed
URL for project: http://www.wihrd.soton.ac.uk
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England
MeSH Terms
  • Hyperbaric Oxygenation
  • Osteoradionecrosis
Organisation Name: Wessex Institute for Health Research and Development
Contact Address: Pauline King. Wessex Institute for Health Research and Development, Boldrewood Medical School, Bassett Crescent East, Highfield, Southampton. SO16 7PX Tel. +44 1703 595661 Fax +44 1703 595662
Copyright: Bazian Ltd, Wessex Institute for Health Research and Development
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