Insulin pumps, conventional and intensive multiple injection insulin therapy for type 1 diabetes mellitus

Oduneye F
Record ID 32004000043
Authors' objectives:

This study aims to assess the effects of continuous insulin infusion pumps compared with multiple injection and conventional insulin therapy in people with type 1 diabetes mellitus.

Authors' recommendations: We found good evidence that intensive insulin therapy improves glucose control and reduces microvascular complications compared with conventional treatment in people with uncomplicated and poorly controlled type 1 diabetes mellitus, although absolute risk reductions associated with treatment are likely to be greater in those with higher baseline risk. However, intensive treatment is associated with increased risk of severe hypoglycaemic episodes and ketoacidosis. We found limited evidence to compare insulin pumps with multiple insulin injection. Limited evidence suggests that insulin pumps may improve glucose control but increase the risk of ketoacidosis compared with multiple injection. We found no evidence to compare insulin pumps and multiple injections for chronic diabetic complications.
Authors' methods: Review
Project Status: Completed
URL for project:
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England
MeSH Terms
  • Diabetes Mellitus, Type 1
  • Drug Delivery Systems
  • Insulin
  • Insulin Infusion Systems
Organisation Name: Wessex Institute for Health Research and Development
Contact Address: Pauline King. Wessex Institute for Health Research and Development, Boldrewood Medical School, Bassett Crescent East, Highfield, Southampton. SO16 7PX Tel. +44 1703 595661 Fax +44 1703 595662
Copyright: Bazian Ltd, Wessex Institute for Health Research and Development
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