Non-ionic contrast media: clinical relevance of different CM-products
Wild C, Puig S
Record ID 32004000019
German
Authors' objectives:
It was the aim of the assessment to analyze the many different non-ionic (monomer) contrast media (NI-CM) products on the actual clinical relevance of their differences in order to give advice for a more concerted purchasing of CM.
In the context of the increasing economic pressure upon hospital-budgets, considerations on central purchasing of pharmaceuticals arise. The assessment was carried out (and paid by) the biggest Austrian hospital cooperation (25% of hospital market). Seven different NI-CM are used in routine care.
Authors' recommendations:
Osmolality, nephrotoxicity, viscosity, hydrophilicity and electric charge are the criteria along which the CM can be differentiated.
The analyzed NI-CM show similar pharmacokinetic and dynamic attributes.
All analyzed NI-CM are safe in their application. The incompatibility and adverse reactions are minimal, the diagnostic accuracy at a comparable high level.
If the iodine concentration and the (intravasal) application protocol are similar, there are only minimal or not reproducible differences concerning safety and diagnostic quality, There are no clinical relevant differences between the seven (analyzed) different non-ionic monomer CM-products.
Along valid definitions, the products are me-too preparations - under patent protection.
In reaction to the many me-too pharmaceuticals and the enormous price differences between EU-countries, the purchasing units of hospitals have started to react: quite interesting models evolve.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://eprints.hta.lbg.ac.at/596/
Year Published:
2003
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Austria
MeSH Terms
- Contrast Media
- Radiology
Contact
Organisation Name:
Institute of Technology Assessment
Contact Address:
Ludwig Boltzmann Institut fur Health Technology Assessment, Garnisongasse 7/rechte Stiege Mezzanin (Top 20) 1090 Vienna, Austria. Tel: +43 (0)1 236 8119 12; Fax: +43 (0)1 236 8119 99
Contact Name:
beate.guba@hta.igb.ac.at
Contact Email:
beate.guba@hta.igb.ac.at
Copyright:
Institute of Technology Assessment (ITA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.