Liquid-based cytology and human papillomavirus testing in cervical cancer screening
Noorani H Z, Brown A, Skidmore B, Stuart G C E
Record ID 32004000008
English, French
Authors' objectives:
To compare the diagnostic accuracy of liquid-based cytology (LBC) and human papillomavirus (HPV) testing with that of Papanicolaou (Pap) smears in the detection of precancerous or malignant cervical lesions.
To evaluate the comparative cost and cost-effectiveness of LBC and HPV testing.
Authors' recommendations:
Diagnostic Accuracy: Seventeen reports on 13 unique trials undertaken in nine countries met the selection criteria for comparing LBC and Pap smears; 23 unique trials met the criteria for comparing HPV testing and Pap smears. Interpretation of the results is hampered by the failure of some trials to meet several validity criteria: in particular, not all women received the reference test. Evidence (based primarily on results from split-sample trials) suggests that compared with Pap smears, the use of LBC reduces the proportion of unsatisfactory specimens and generates fewer false negatives for ordinary populations, but not for high-risk populations. HPV testing, alone or with cytology, is more sensitive but less specific than Pap smears.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
https://www.ccohta.ca/
Year Published:
2003
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Papillomavirus Infections
- Uterine Cervical Neoplasms
- Vaginal Smears
Contact
Organisation Name:
Canadian Coordinating Office for Health Technology Assessment
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553, Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Coordinating Office for Health Technology Assessment (CCOHTA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.