Does salpingectomy reduce the risk of ovarian cancer?

Darelius A, Freadrich K, Kristjansdottir B, Lycke M, Persson J, Strandell A, Sundfeldt K, Svanberg T, Kindblom JM
Record ID 32018011368
English
Authors' objectives: Background Recent findings indicate that the Fallopian tubes are central for the development of epithelial ovarian cancer (EOC), and that the ovary is involved secondarily. This has changed the understanding of the origin of EOC. For premenopausal women at average risk of ovarian cancer, the benefits with an opportunistic oophorectomy (removal of the ovaries) at the time of hysterectomy do not outweigh the risks. However, based on the new theory of EOC origin, it has been argued that removal of the Fallopian tubes would reduce the risk of EOC. Objective This report evaluates if opportunistic salpingectomy in women undergoing benign hysterectomy or other abdominal gynaecological surgical procedures, reduces the incidence of ovarian cancer, affects survival, health related quality of life (HRQoL), ovarian function, duration of surgery or hospital stay.
Authors' results and conclusions: Opportunistic salpingectomy at the time of hysterectomy for a benign indication has not been evaluated for risk reduction of ovarian cancer. Salpingectomy by indication has been compared only with no surgery. Importantly, the risk for complications, particularly procedure-induced menopause, is insufficiently evaluated. Thus, despite a biological rationale for removal of the Fallopian tubes, benefits with the procedure have not been confirmed, and the risk of complications or adverse effects of the procedure is not yet fully elucidated. Adding salpingectomy to a hysterectomy may slightly increase the duration of surgery and the cost correspondingly.
Details
Project Status: Completed
Year Published: 2016
URL for published report: https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/su4372-1728378332-322/native/2016_86%20HTA-rapport%20Does%20salpingectomy%20reduce%20the%20risk%20of%20ovarian%20cancer.pdf
English language abstract: An English language summary is available
Publication Type: Full HTA
MeSH Terms
  • Ovarian Neoplasms
  • Salpingectomy
  • Hysterectomy
  • Carcinoma, Ovarian Epithelial
Keywords
  • Opportunistic salpingectomy
Contact
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
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