Positron emission tomography and computed tomographic imaging prior to radiotherapy for anal cancer
Albertsson P, Björkander E, Hallqvist A, Liljegren A, Månsson C, Strandell A, Samuelsson O
Record ID 32018011367
English
Authors' objectives:
Background
Anal cancer is a rare malignant disease that in many cases can be treated with organ-conserving treatment. Chemoradiation therapy is the cornerstone in such therapy. A combination of positron emission tomography (PET) and computed tomographic (CT) imaging (PET/CT) may provide the radiation therapist with more accurate data on primary tumour extension within nearby tissues, as well as data on involvement of lymph nodes. It is plausible that this technology would better select suitable patients for curative radiation therapy, as well as to increase the likelihood to correctly delineate tumour tissue. Hereby, the probability to achieve an improved tumour control, and in the long run an improved survival, may be increased. Furthermore, the radiation to normal tissue will decrease and, thereby, reduce radiation-induced side effects.
Objective To evaluate whether the combination of PET and CT is superior to CT alone for target delineation and radiotherapy planning in patients with anal cancer suitable for curative radiotherapy treatment.
Authors' results and conclusions:
The use of PET/CT (dose planning) probably results in an important change in target definition (GRADE ⊕⊕⊕), and may result in an important change of treatment intent from curative to palliative (GRADE ⊕⊕). The prognostic impact on survival and quality of life still remains to be clarified.
Details
Project Status:
Completed
Year Published:
2016
English language abstract:
An English language summary is available
Publication Type:
Full HTA
MeSH Terms
- Anus Neoplasms
- Radiotherapy
- Radiotherapy, Image-Guided
- Positron Emission Tomography Computed Tomography
- Tomography, X-Ray Computed
Contact
Organisation Name:
The Regional Health Technology Assessment Centre
Contact Address:
The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name:
hta-centrum@vgregion.se
Contact Email:
hta-centrum@vgregion.se
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