Positron emission tomography and computed tomographic imaging prior to radiotherapy for lung cancer

Hallqvist A, Albertsson P, Björkander E, Liljegren A, Månsson C, Strandell A, Samuelsson O
Record ID 32018011366
English
Authors' objectives: Background Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) comprise the great majority of all lung cancer and have a high risk of premature death. Many patients are diagnosed with a severity of their disease that is too advanced for surgery but without distant metastatic spread. They can be treated with curative intent with high dose irradiation and chemotherapy. A proposed management to better select suitable patients to high dose radiation therapy as well as to increase the likelihood to correctly delineate tumour tissue, is to use the combination of Positron Emission Tomography (PET) and CT (PET/CT) for dose planning purposes in the radiotherapy work-up instead of merely a dose planning CT. The intention is to achieve an improved tumour control and decrease radiation to normal surrounding tissue, and thus minimise side effects and possibly improve survival. Objective To evaluate whether the combination of PET and CT is superior to CT alone for target delineation and radiotherapy planning in adult patients with lung cancer suitable for curative radiotherapy treatment, and whether this will lead to improved survival and increased quality of life.
Authors' results and conclusions: The use of PET/CT (dose planning) may improve survival (GRADE ⊕⊕OO). It probably result in changes in target definition (GRADE ⊕⊕⊕O), and in treatment intent from curative to palliative (GRADE ⊕⊕⊕O). The prognostic impact on quality of life still remains to be clarified.
Details
Project Status: Completed
Year Published: 2016
URL for published report: https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/su4372-1728378332-323/native/2016_88%20HTA-rapport%20Positron%20Emission%20Tomography%20and%20Computed%20Tomographic%20Imaging%20Prior%20to%20Radiotherapy%20for%20Lung%20Cancer.pdf
English language abstract: An English language summary is available
Publication Type: Full HTA
MeSH Terms
  • Lung Neoplasms
  • Radiotherapy
  • Radiotherapy, Image-Guided
  • Positron Emission Tomography Computed Tomography
  • Carcinoma, Non-Small-Cell Lung
  • Tomography, X-Ray Computed
Contact
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
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