Acellular dermal matrix support for breast reconstruction after mastectomy
Hallberg H, Lewin R, Rafnsdottir S, Samuelsson O, Selvaggi G, Stadig I, Svanberg T, Strandell A
Record ID 32018011362
English
Authors' objectives:
Background
Long term survival after treatment for breast cancer has improved during the last decades. The need of breast reconstruction has therefore increased, both after therapeutic and prophylactic mastectomy. Immediate breast reconstruction (IBR) i.e. at the same time as the cancer surgery is increasingly often used. The surgical methods have changed towards preservation of the nipple-areola complex and skin, in an attempt to improve the final aesthetic result. To meet the demand for a proper pocket for the implant at IBR, different supporting materials like acellular dermal matrix (ADM) or synthetic matrix have been introduced.
Objective
To evaluate whether there is a difference in recurrence of cancer, major complication rates, health related quality of life (HRQoL) or aesthetic outcome when ADM (including all types) is used in immediate breast reconstruction compared to reconstruction without ADM.
Authors' results and conclusions:
Despite a large number of studies of immediate breast reconstruction after mastectomy in women at risk or with breast cancer, the certainty of evidence is low or very low for efficacy and safety of acellular dermal matrix. There are no studies on recurrence of cancer or HRQoL. Randomised controlled trials are urgently needed.
Details
Project Status:
Completed
Year Published:
2017
English language abstract:
An English language summary is available
Publication Type:
Full HTA
MeSH Terms
- Mastectomy
- Mammaplasty
- Acellular Dermis
- Breast Neoplasms
Keywords
- Acellular dermal matrix
- Breast reconstruction
Contact
Organisation Name:
The Regional Health Technology Assessment Centre
Contact Address:
The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name:
hta-centrum@vgregion.se
Contact Email:
hta-centrum@vgregion.se
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.