Efficacy of sleep deprivation in patients with depression including bipolar depression

Ioannou M, Greenbrook JTV, Larson T, Magnusson K, Stadig I, Schmitz L, Sjögren P, Steingrimsson S, Svensson M, Szábo Z, Wartenberg C
Record ID 32018011344
English
Authors' objectives: The objective of this Health Technology Assessment (HTA) was to assess whether total sleep deprivation with or without subsequent light therapy is an effective treatment for patients with depression or bipolar depression compared with no sleep deprivation or other treatment - by itself or in addition to standard treatment. Mortality, self-harm, and depression symptoms were considered critical outcomes for decision making. Important outcomes were quality of sleep, health-related quality of life (HRQl), medication use, everyday functioning, length of hospital stay, complications, and patients’ experiences during treatment. Diurnal rhythm was considered a less important outcome.
Authors' results and conclusions: Mortality and self-harm have not been investigated in the included studies on sleep deprivation in patients with depression. Based on six RCTs, with several study limitations and imprecision, sleep deprivation compared with no add-on treatment may have little transient or no effect on depressive symptoms (low certainty of evidence, GRADE ⊕⊕). Based on one RCT in patients starting antidepressant medication, sleep deprivation with subsequent chronotherapeutic maintenance may reduce depressive symptoms compared with exercise of limited intensity and duration (low certainty of evidence, GRADE ⊕⊕). It is uncertain whether sleep deprivation affects depressive symptoms compared to medication, and whether sleep deprivation affects the level of functioning, HRQl, or duration of hospital stay compared with no or other treatment (very low certainty of evidence, GRADE ⊕). Medication use and diurnal rhythm were not systematically studied, and information on complications was sparse.
Details
Project Status: Completed
Year Published: 2019
URL for published report: https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/su4372-1728378332-347/native/2019_110%20HTA-rapport%20Vakenhetsterapi.pdf
English language abstract: An English language summary is available
Publication Type: Full HTA
MeSH Terms
  • Depressive Disorder
  • Bipolar Disorder
  • Depression
  • Chronotherapy
  • Sleep Deprivation
  • Phototherapy
Keywords
  • Sleep deprivation
Contact
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.