Anti-inflammatory, antibiotic and immunomodulatory treatment in children with symptoms corresponding to the research condition PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)
Johnson M, Ehlers S, Fernell E, Hajjari P, Svanberg T, Vikberg Adania U, Wartenberg C, Wallerstedt SM
Record ID 32018011334
English
Authors' objectives:
Does anti-inflammatory, antibacterial or immunomodulatory treatment, compared with no such treatment, improve health-related quality of life (HRQL), level of functioning and symptoms in children with symptoms corresponding to the research condition of PANS/PANDAS? Is such treatment associated with complications?
Authors' results and conclusions:
In children with acute-onset OCD or restricted food intake, together with two or more neuropsychiatric symptoms and without a verified neurologic or medical disease (corresponding to the research condition of PANS/PANDAS), this HTA reveals very low certainty of evidence that antiinflammatory, antibacterial or immunomodulating treatments would improve the level of functioning or
reduce symptoms. Patient data for these outcomes are limited, and evidence regarding potential effects on HRQL is lacking. There is moderate certainty evidence that side effects known from use in other indications can occur.
Details
Project Status:
Completed
Year Published:
2020
URL for published report:
https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/su4372-1728378332-387/native/2020_115%20HTA-rapport%20PANS%20PANDAS.pdf
English language abstract:
An English language summary is available
Publication Type:
Full HTA
MeSH Terms
- Obsessive-Compulsive Disorder
- Child
- Autoimmune Diseases
- Anti-Bacterial Agents
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Immunomodulation
- Immunomodulating Agents
- Immunoglobulins, Intravenous
Keywords
- PANS
- PANDAS
- Pediatric Acute-onset Neuropsychiatric Syndrome
Contact
Organisation Name:
The Regional Health Technology Assessment Centre
Contact Address:
The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name:
hta-centrum@vgregion.se
Contact Email:
hta-centrum@vgregion.se
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.