Clinical effects of preoperative i.v. iron infusion in patients with colorectal cancer and iron-deficiency anemia
de la Croix H, Magnusson K, Sheikhan E, Sjögren P, Svanberg T, Svensson M, Sjövall H
Record ID 32018011322
English
Authors' objectives:
Background: Preoperative iron deficiency anemia is common in patients with colorectal cancer. Traditionally, anemic patients are given oral iron substitution before colorectal cancer surgery, but this strategy has recently been questioned since intravenous (i.v.) iron substitution compounds have become available. The aim of this HTA was to evaluate the evidence for this new strategy.
Question at issue: Does preoperative iron infusion reduce mortality, risk for tumour recurrence, risk of perioperative complications, need for reoperation, or the need for blood transfusions, and does it improve health-related quality of life or reduce length of hospital stay, as compared with conventional treatment (placebo infusion, no treatment or oral iron substitution), in patients planned for operative treatment of colorectal cancer with a haemoglobin level below 115 g/l?
Authors' results and conclusions:
General concluding remark:
Robust scientific evidence to evaluate the effect of i.v. iron compounds in CRC patients is lacking. Even if no evidence was demonstrated that treatment of this patient group with i.v. iron compounds improves major clinical outcomes, as compared to either no treatment or oral iron substitution, the 95% CI:s are wide. One therefore cannot exclude clinically important differences. Low or very low certainty of evidence.
Details
Project Status:
Completed
Year Published:
2021
URL for published report:
https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/su4372-1728378332-396/native/2021_124%20HTA-rapport%20J%c3%a4rninfusion.pdf
English language abstract:
An English language summary is available
Publication Type:
Full HTA
MeSH Terms
- Colorectal Neoplasms
- Colorectal Surgery
- Anemia, Iron-Deficiency
- Iron Compounds
- Administration, Intravenous
- Iron
- Blood Transfusion
- Preoperative Care
Contact
Organisation Name:
The Regional Health Technology Assessment Centre
Contact Address:
The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name:
hta-centrum@vgregion.se
Contact Email:
hta-centrum@vgregion.se
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.