Efficacy and safety of advanced hybrid closed loop systems compared with multiple daily injections or open loop systems, in adults with type 1 diabetes

Eeg-Olofsson K, Hero C, Khan J, Petzold M, Sjögren P, Sjövall H Stadig I, Svanberg T, Hongslo Vala C
Record ID 32018011311
Authors' objectives: Does the use of advanced hybrid closed loop insulin pump system, compared with multiple daily injections with sensor based continuous glucose monitoring or a more traditional insulin pump (sensor augmented pump or separate pump and sensor), improve blood glucose control and quality of life and reduce the risk of diabetes complications in adults with type 1 diabetes, without compromising safety?
Authors' results and conclusions: This HTA report shows that in a high-risk population, as reflected by increased baseline HbA1c, AHCL may result in a large increase in TIR and a slight decrease in TAR. It may also result in clinically relevant reductions of HbA1c compared with baseline, when compared with MDI with sensor. In a normal-risk population, AHCL probably improves the sensor-related glycaemic outcomes TIR, TBR and TAR when compared with SAP, but had no consistent effect on HbA1c and it was uncertain whether AHCL improves patient satisfaction measured with validated instruments. A major shortcoming of the documentation is that the effects on long-term complications of the consistent but numerically moderate changes in the glycaemic variables is unknown.
Project Status: Completed
Year Published: 2023
English language abstract: An English language summary is available
Publication Type: Full HTA
MeSH Terms
  • Diabetes Mellitus, Type 1
  • Pancreas, Artificial
  • Insulin Infusion Systems
  • Adult
  • Hypoglycemic Agents
  • Advanced hybrid closed loop
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.