Bone marrow and peripheral blood stem cell transplantation for malignancy: a review

Johnson P W M, Simnett S J, Sweetenham J W Morgan G J, Stewart L A
Record ID 31998008905
Authors' objectives:

To assess the relative effectiveness of high-dose myeloablative therapy and progenitor cell transplantation (HDT/PCT) compared with conventional therapy for the treatment of malignancy.

To assess the relative cost of HDT/PCT versus conventional chemotherapy (CC).

To assess the efficacy and cost of bone marrow transplantation (BMT) versus peripheral blood progenitor cells transplantation (PBPCT).

Authors' recommendations: As a whole the review has found no conclusive evidence that HDT/PCT is superior to conventional treatment in terms of survival or PFS. Conversely, it has not demonstrated that it is inferior. Given the overall pattern of results, HDT/PCT appears to be a therapy worthy of further exploration. As few prospective economic analyses were identified it is not possible accurately to determine the comparative cost of HDT/PCT and CC.
Authors' methods: Systematic review
Project Status: Completed
URL for project:
Year Published: 1998
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Controlled Clinical Trials as Topic
  • Costs and Cost Analysis
  • Female
  • Male
  • Middle Aged
  • Treatment Outcome
  • Bone Marrow Transplantation
  • Breast Neoplasms
  • Hematologic Neoplasms
  • Hematopoietic Stem Cell Transplantation
  • Lung Neoplasms
  • Lymphoma
  • Multiple Myeloma
  • Neoplasms
  • Ovarian Neoplasms
  • Testicular Neoplasms
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
Contact Email:
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This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.