Authors' objectives:

The objective of this assessment is to determine the effectiveness, safety and cost implication of routine administration of vitamin K at birth for the prevention of vitamin K deficiency bleeding (VKDB) or haemorrhagic disease of newborn (HDN).

Authors' recommendations: From this assessment, it can be concluded that there is sufficient evidence on the safety of vitamin K. With respect to effectiveness there is sufficient evidence to support vitamin K in preventing VKDB. A selective policy of vitamin K administration after screening is not appropriate since relatively high incidence of both classic and late VKDB occurred without prophylaxis. The evidence on a comparison of parenteral with intramuscular route of administration appears inconclusive, however there is sufficient evidence to show that oral regimens are effective. In relation to starting oral regimen, ethnical and geographical differences in vitamin K metabolism and absorption, incidence of underlying disease, breastfeeding patterns and uptake would need to be considered. In the area of cost implications, there is insufficient evidence, although there is some evidence that it is cost effective. It is recommended that an intramuscular dose of vitamin K be given to all newborns at birth as prophylaxis to prevent VKDB.

Authors' methods: Systematic review

Project Status: Completed

URL for project: http://www.moh.gov.my/

Year Published: 2002

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Malaysia

Organisation Name: Malaysian Health Technology Assessment Unit

Contact Address: Health Technology Assessment Unit, Medical Development Division, Ministry of Health Malaysia, Level 21, PERKIM Building, Jalan Ipoh, 51200 Kuala Lumpur, Malaysia. Tel: 603 4045 7781, Fax: 603 4045 77 40

Copyright: Malaysian Health Technology Assessment Unit (MHTAU)