5-fluorouracil (5-FU) as adjuvant chemotherapy in Duke's stage C colorectal cancer

Bliss E, Robert G
Record ID 31998008877
Authors' objectives:

The authors examine how worthwhile is the proposal that all patients with Duke's stage C colorectal cancer be offered 5-fluorouracil (5-FU) as adjuvant chemotherapy following surgery.

Authors' results and conclusions: 100 patients given 5-FU/FA would be expected to gain 24 life years compared with respective patients randomised to receive surgery alone. The results for 5-FU/levamisole were similar (23 life years gained).
Authors' recommendations: There are undoubted benefits, but in view of side effects the cost of QALYs is likely to be at the upper end of the range.
Authors' methods: Review
Project Status: Completed
URL for project: http://www.wihrd.soton.ac.uk
Year Published: 1996
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England
MeSH Terms
  • Chemotherapy, Adjuvant
  • Costs and Cost Analysis
  • Colorectal Neoplasms
Organisation Name: Wessex Institute for Health Research and Development
Contact Address: Pauline King. Wessex Institute for Health Research and Development, Boldrewood Medical School, Bassett Crescent East, Highfield, Southampton. SO16 7PX Tel. +44 1703 595661 Fax +44 1703 595662
Copyright: Wessex Institute for Health Research and Development (WIHRD)
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