Prestorage filtration of blood components for patients who are chronically transfusion dependent
Beck S, Stevens A
Record ID 31998008871
Filtration of blood components which are to be transfused to chronically transfusion dependent patients reduces the number of white blood cells in the component, to a level at which they are unlikely to cause harmful sequelae. Leucodepletion prestorage, rather than at the bedside, is proposed to be more effective. The author aims to investigate how reliable this proposal is.
Authors' results and conclusions:
The trials which consider prestorage leucodepletion have demonstrated that it is an effective method. Adverse consequences are reduced when prestorage rather than standard products are used. However a further conclusion these studies identify is that prestorage leucodepletion does not have conclusive benefits for patients with a positive risk history.
Prestorage filtration is theoretically preferable to no leucodepletion or bedside filtration, that is, it is expected to be more effective in reducing the incidence of FTRs, alloimmunization and refractoriness. However, the author concludes that the quality of the evidence is insufficient to quantify the benefits.
English language abstract:
An English language summary is available
- Blood Preservation
- Blood Transfusion
- Cell Separation
Wessex Institute for Health Research and Development
Pauline King. Wessex Institute for Health Research and Development, Boldrewood Medical School, Bassett Crescent East, Highfield, Southampton. SO16 7PX Tel. +44 1703 595661 Fax +44 1703 595662
Wessex Institute for Health Research and Development (WIHRD)