Comparative incidence of heparin-induced thrombocytopenia syndrome (HITS) with unfractionated heparin and low molecular weight heparin

Jackson N
Record ID 32003000709
Authors' objectives:

This aim of this report was to assess the comparative incidence of HITS with heparin (unfractionated) and low molecular weight heparin.

Authors' recommendations: - Eight studies were identified which assessed thrombocytopenia or heparin-induced thrombocytopenia syndrome (HITS) in general surgery patients, orthopaedic surgery patients or cardiac surgery patients - Six studies showed that the incidence of thrombocytopenia or HITS was lower in patients who received low molecular weight heparin (LMWH) compared to patients who received unfractionated heparin (UFH), regardless of type of surgery - Only three studies confirmed the diagnosis of HITS by means of the presence of heparin-dependent antibodies - Methodological limitations and small sample sizes of many of the studies identified limit the ability to determine the true incidence of HITS and time of onset - Further research, examining HITS as a primary outcome, is required to elucidate the incidence of HITS with the use of unfractionated or low molecular weight heparin for the prophylaxis of venous thromboembolism
Authors' methods: Review
Project Status: Completed
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Australia
MeSH Terms
  • Heparin
  • Heparin, Low-Molecular-Weight
  • Thrombocytopenia
Organisation Name: Centre for Clinical Effectiveness
Contact Address: Monash Institute of Health Services Research, Block E, Monash Medical Centre, Locked Bag 29, Clayton, Victoria 3168, Australia. Tel: +61 3 9594 7505; Fax: +61 3 9594 7552.
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Copyright: Centre for Clinical Effectiveness (CCE)
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