Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin

Muggli E
Record ID 32003000705
Authors' objectives:

This aim of this report was to assess which antibiotic regimen is more appropriate for acute appendicitis: Ampicillin, metronidazole plus gentamycin or cephalosporin (+/- metronidazole).

Authors' recommendations: - One randomised trial was reviewed that met inclusion and exclusion criteria. - The trial combined children with appendicitis from the age of 12 years with adults to the age of 48 years. - This study found ceftriaxone, a cephalosporin, to be equally effective as a triple regimen of ampicillin, metronidazole plus gentamycin in the prophylaxis for postoperative sepsis.
Authors' methods: Review
Project Status: Completed
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Australia
MeSH Terms
  • Anti-Bacterial Agents
  • Appendicitis
Organisation Name: Centre for Clinical Effectiveness
Contact Address: Monash Institute of Health Services Research, Block E, Monash Medical Centre, Locked Bag 29, Clayton, Victoria 3168, Australia. Tel: +61 3 9594 7505; Fax: +61 3 9594 7552.
Contact Name:
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Copyright: Centre for Clinical Effectiveness (CCE)
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