Colloid or crystalloid solutions for fluid resuscitation
Bernath V
Record ID 32003000690
English
Authors' objectives:
This aim of this report was to assess whether colloid solutions are more effective than crystalloid solutions in the treatment of shock and related conditions.
Authors' recommendations:
- Three systematic reviews meeting inclusion and exclusion criteria were retrieved. A relevant technology assessment was also identified but could not be obtained for appraisal.
- The three systematic reviews agree that colloid solutions demonstrate no advantage over crystalloid solutions for fluid resuscitation in trauma patients.
- The reviews differ in their conclusions about the use of colloids in general: - The most recent review which has excluded studies of certain patient groups, suggests that the use of colloids is unwarranted outside further trials. - The 1999 review has also found no clear difference between the use of colloid and crystalloid solutions but cautions that these results should be considered carefully. Other factors of possible significance are cited as comorbidity, illness severity and acquired complications which have not been addressed by the identified studies, and insufficient power to identify significant differences due to small patient numbers. - The earliest review suggests that in the appropriate setting colloid therapy may be more efficacious in the nontrauma patient.
- The two recent reviews have identified methodological problems with the included studies which include: - Poor randomisation of patients to treatment groups - Lack of allocation concealment - Non-blinding of care givers
- Each of the reviews includes studies published before 1990, which may not reflect current practice in patient care.
Authors' methods:
Review
Details
Project Status:
Completed
URL for project:
http://www.med.monash.edu.au/healthservices/cce/evidence/
Year Published:
2001
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Colloids
- Fluid Therapy
- Shock
- Shock, Traumatic
Contact
Organisation Name:
Centre for Clinical Effectiveness
Contact Address:
Monash Institute of Health Services Research, Block E, Monash Medical Centre, Locked Bag 29, Clayton, Victoria 3168, Australia. Tel: +61 3 9594 7505; Fax: +61 3 9594 7552.
Contact Name:
cce@med.monash.edu.au.
Contact Email:
cce@med.monash.edu.au.
Copyright:
Centre for Clinical Effectiveness (CCE)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.