What is the optimal dose of intravenous corticosteroid for initial management of acute exacerbations of asthma and COPD?
Hender K
Record ID 32003000673
English
Authors' objectives:
This aim of this report was to assess the optimal dose of intravenous corticosteroid for initial management of acute exacerbations of asthma and COPD.
Authors' recommendations:
- One systematic review was identified that met the inclusion and exclusion criteria
- Varying doses of corticosteroids used in the treatment of admitted patients with acute asthma appear to result in similar outcomes when pulmonary function data are examined.
- Higher doses of corticosteroids do not appear to have an obvious therapeutic advantage for severe asthma patients
- The results may not be generalisable to COPD patients, mild asthmatics, or patients with ventilatory support.
- We are unable to determine the effect of differing doses of corticosteroids on time to discharge, adverse events or quality of life.
- We are unable to reach conclusions regarding the dosing effect for intravenous and oral corticosteroids individually.
Authors' methods:
Review
Details
Project Status:
Completed
URL for project:
http://www.med.monash.edu.au/healthservices/cce/evidence/
Year Published:
2000
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Adrenal Cortex Hormones
- Asthma
- Pulmonary Disease, Chronic Obstructive
Contact
Organisation Name:
Centre for Clinical Effectiveness
Contact Address:
Monash Institute of Health Services Research, Block E, Monash Medical Centre, Locked Bag 29, Clayton, Victoria 3168, Australia. Tel: +61 3 9594 7505; Fax: +61 3 9594 7552.
Contact Name:
cce@med.monash.edu.au.
Contact Email:
cce@med.monash.edu.au.
Copyright:
Centre for Clinical Effectiveness (CCE)
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