Serum antibodies for the diagnosis of inflammatory bowel disease (IBD): pANCA for ulcerative colitis (UC) and ASCA for Crohn's disease (CD)
Institute for Clinical Systems Improvement
Record ID 32003000568
English
Authors' objectives:
This review aims to assess the available evidence on the effectiveness of serum antibodies for the diagnosis of inflammatory bowel disease (IBD): pANCA for ulcerative colitis (UC) and ASCA for Crohn's disease (CD)
Authors' recommendations:
With regard to serum antibodies for diagnosing inflammatory bowel disease (IBD) the ICSI Technology Assessment Committee finds:
The clinical utility of serological testing is not yet established for the diagnosis of inflammatory bowel disease in patients presenting with symptoms suggestive of IBD (Conclusion Grade III).
The clinical utility of serological testing is not yet established for differentiating between UC and CD in patients with inflammatory bowel disease (Conclusion Grade II).
Although serum testing is a safe procedure, there are risks associated with false negative and false positive test results. Consequences due to false negative and false positive test results have not been evaluated.
There are well-established radiologic, histologic, and endoscopic techniques for diagnosing IBD and differentiating CD and UC.
There appears to be a high inter-laboratory variability of sensitivities and specificities.
Authors' methods:
Review
Details
Project Status:
Completed
URL for project:
http://www.icsi.org/index.asp
Year Published:
2002
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Colitis, Ulcerative
- Crohn Disease
- Inflammatory Bowel Diseases
Contact
Organisation Name:
Institute for Clinical Systems Improvement
Contact Address:
8009 34th Avenue South, Suite 1200, Bloomington, MN, USA. Tel: +1 952 814 7060; Fax: +1 952 858 9675
Contact Name:
icsi.info@icsi.org
Contact Email:
icsi.info@icsi.org
Copyright:
Institute for Clinical Systems Improvement (ICSI)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.