Antibiotic products for treatment of trauma-related osteomyelitis

Mitchell MD, Brennan PJ, Mull NK
Record ID 32018005542
Authors' objectives: Identify health technology assessment reports and systematic reviews relating to antibiotic-laden bone cement, antibiotic beads or pellets, and related products for the treatment of bone infections in trauma patients.
Authors' results and conclusions: ▪ We conducted a limited search for high-level evidence on antibiotic-laden bone cement, beads, and related products for the treatment of osteomyelitis in trauma patients. Because only a small amount of high-level evidence was found, we extended the search to primary studies in the MEDLINE database. ▪ Health technology assessment reports on these products did not address treatment indications. ▪ A few systematic reviews addressed the treatment indication. The Cochrane review on antibiotics for treatment of osteomyelitis (not updated since 2013) did not find any randomized trials of antibiotic cements, beads, or other products for this indication. More recent reviews confirm that the evidence base is still small and of low quality. ▪ While there are some controlled trials of these products for the prevention of osteomyelitis, the evidence base on antibiotic products for the treatment of osteomyelitis in trauma patients is made up almost entirely of uncontrolled case series. Because of differences in study design, patient population, and outcomes measurement, they are not sufficient evidence to support any conclusions about the effectiveness and safety of these products for this indication. ▪ We have not reviewed the full text of these articles. Please contact CEP for a full review of evidence should you have further questions about this topic or would like analysis of the evidence for a specific patient group or comparison.
Project Status: Completed
Year Published: 2023
English language abstract: An English language summary is available
Publication Type: Other
Country: United States
MeSH Terms
  • Polycarboxylate Cement
  • Osteomyelitis
  • Anti-Bacterial Agents
  • Bone Substitutes
  • Bone Cements
  • Wound Healing
  • osteomyelitis
  • cement
  • beads
Organisation Name: Penn Medicine Center for Evidence-based Practice
Contact Address: Penn Medicine Center for Evidence-based Practice, University of Pennsylvania Health System, 3600 Civic Center Blvd, 3rd Floor West, Philadelphia PA 19104
Contact Name: Nikhil Mull
Contact Email:
Copyright: <p>Center for Evidence-based Practice (CEP)</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.