[Effectiveness and complications of preimplantation genetic testing for aneuploidies (PGT-A) in in vitro fertilisation (IVF)]

Record ID 32018005282
Original Title: Kan undersökning av avvikelser i embryots kromosomer leda till att antalet födslar ökar vid assisterad befruktning? - Effekter och komplikationer av preimplantatorisk genetisk testning-aneuploidi (PGT-A) vid in vitro fertilisering (IVF)
Authors' objectives: Preimplantation genetic testing for aneuploidies (PGT-A) is a form of prenatal genetic diagnosis of embryos to detect abnormal chromosome numbers before insertion of the embryo during in vitro fertilisation (IVF). An abnormal number of chromosomes can increase the risk for early miscarriage and is more common in older women. Theoretically, if only embryos with a normal number of chromosomes are inserted it increases the chances of a successful IVF treatment. We will investigate the following questions: What effect does preimplantation genetic testing – aneuploidy (PGT-A), with analysis of all chromosomes, in in vitro fertilization (IVF) have on outcomes related to pregnancy and quality of life? Which complications can preimplantation genetic testing (irrespective of type of PGT) lead to for the child and the pregnant woman? What is the relationship between costs and effects of IVF with PGT-A compared to IVF without PGT-A? Which ethical aspects of relevance in the Swedish context are associated with PGT-A in IVF?
Project Status: Ongoing
Anticipated Publish Date: 2025
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Sweden
MeSH Terms
  • Fertilization in Vitro
  • Genetic Testing
  • Aneuploidy
  • Preimplantation Diagnosis
  • in vitro fertilization
  • IVF
  • intracytoplasmic sperm injection
  • embryo transfer
  • assisted reproduction
  • preimplantation genetic testing
  • preimplantation genetic screening
  • PGS
  • PGT
  • PGT-A
  • aneuploidy
  • chromosome analysis
  • biopsy
  • blastocyst biopsy
  • systematic review
  • health technology assessment
  • health economics
Organisation Name: Swedish Agency for Health Technology Assessment and Assessment of Social Services
Contact Address: SBU – Swedish Agency for Health Technology Assessment and Assessment of Social Services, P.O. Box 6183, SE-102 33 Stockholm, Sweden. Tel: +46 8 4123200, Fax: +46 8 4113260
Contact Name: registrator@sbu.se
Contact Email: registrator@sbu.se
Copyright: SBU – Swedish Agency for Health Technology Assessment and Assessment of Social Services
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