Original Title: Preimplantatorisk genetisk testning av kromosomavvikelser (PGT-A) vid in vitro-fertilisering (IVF)

Authors' objectives: Preimplantation genetic testing for aneuploidies (PGT-A) is a form of prenatal genetic diagnosis of embryos to detect abnormal chromosome numbers before insertion of the embryo during in vitro fertilisation (IVF). Embryos are normally assessed for morphology before insertion in the woman’s uterus, but with PGT-A embryos are also analysed for the number of chromosomes. An abnormal number of chromosomes can increase the risk for early miscarriage and is more common in older women. Theoretically, if only embryos with a normal number of chromosomes are inserted it increases the chances of a successful IVF treatment. PGT-A is not allowed in Sweden (SFS 2006:351 4 kap 2§), but other forms of preimplantation genetic testing for monogenic/single gene defects (PGT-M) or structural rearrangements (PGT-SR) are. However, PGT-A is used in other countries such as Finland, UK and USA. According to professionals working with IVF in Sweden there is a need for a synthesis of knowledge to find out if PGT-A can increase the chance for a successful IVF treatment for certain groups of patients.

Project Status: Ongoing

URL for project: https://www.sbu.se/en/ongoing-projects/preimplantation-genetic-testing-for-aneuploidies-pgt-a-in-in-vitro-fertilisation-ivf/

Anticipated Publish Date: 2025

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Sweden

Organisation Name: Swedish Agency for Health Technology Assessment and Assessment of Social Services

Contact Address: SBU – Swedish Agency for Health Technology Assessment and Assessment of Social Services, P.O. Box 6183, SE-102 33 Stockholm, Sweden. Tel: +46 8 4123200, Fax: +46 8 4113260

Contact Name: info@sbu.se

Contact Email: info@sbu.se

Copyright: SBU – Swedish Agency for Health Technology Assessment and Assessment of Social Services