Causal association between SARS-Cov-2 infection and the development of trigeminal neuralgia

WorkSafeBC Evidence-Based Practice Group, Martin CW
Record ID 32018005166
Authors' objectives: To determine whether there is any evidence to support the (causal) association between SARS-COV-2 infection and the development of trigeminal neuralgia.
Authors' results and conclusions: Twenty-two published studies were identified from the described above literature search. Upon examination on the titles and abstracts of these twenty-two studies, eleven studies were thought to be relevant and were retrieved in full for further appraisal. Examining these eleven studies, five studies, including one systematic review of case reports on neuropathic pain associated with COVID-19, did not provide any (new) data or were not relevant to the objective of this systematic review and will not be discussed further. Table 1 (please refer to our paper for the table) summarizes all of the cases identified. At present, there is some evidence, coming from low-level and low-quality studies, on the temporal association between the development of trigeminal neuralgia due to SARS-Cov-2 infection. However, based on the available evidence, it is still not possible to assess the causality of such an observed association.
Authors' methods: A systematic literature search was conducted on commercial medical literature databases on January 24, 2023. In identifying literature on COVID-19, we adopted COVID-19 search strings that were developed by the Canadian Agency for Drugs and Technology in Health (CADTH) (available here and combining it with trigeminal neuralgia. The keywords are outlined in full in the systematic literature review. No limitations, such as on the language or country of publication, were implemented in this literature search. A manual search was also conducted on the references of the articles that were retrieved in full.
Project Status: Completed
Year Published: 2023
English language abstract: An English language summary is available
Publication Type: Mini HTA
Country: Canada
MeSH Terms
  • Trigeminal Neuralgia
  • COVID-19
  • Post-Acute COVID-19 Syndrome
  • Coronavirus Infections
  • SARS-CoV-2
  • trigeminal neuralgia
  • trigeminal neuropathy
  • trifacial neuralgia
  • coronavirus
  • long COVID
  • post COVID
  • epidemic
  • outbreak
  • pandemic
  • wuhan
  • hebei
  • pneumonia
Organisation Name: WorkSafeBC
Contact Address: 6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698
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Copyright: WorkSafe BC
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