Transcranial magnetic resonance-guided high-intensity focused ultrasound treatment in patients with drug-resistant essential tremor

Gassner L, Al Froukh RF, Goetz G
Record ID 32018004893
English
Authors' objectives: This systematic review evaluates whether transcranial magnetic resonance-guided high-intensity focused ultrasound treatment (tcMRgFUS) is more effective and safe compared to sham, deep brain stimulation or radiofrequency thalamotomy in patients with drug-resistant essential tremor (ET).
Authors' results and conclusions: One RCT and two retrospective comparative cohort studies were identified. Furthermore, two prospective single-arm observational studies were included for safety outcomes. TcMRgFUS is superior to sham procedure in terms of tremor severity, functional disability, and health-related quality of life at the 3-month follow-up period in patients who are not eligible or not yet eligible for deep brain stimulation. Safety data indicate that tcMRgFUS may be a safe treatment option for this patient population.
Authors' recommendations: For patients eligible for deep brain stimulation, the evidence is insufficient to assess comparative efficacy and safety due to the critical risk of bias and retrospective design. Randomised, comparative studies are needed, focusing on directive comparing tcMRgFUS in patients eligible for deep brain stimulation and long-term safety in large registry-based studies.
Details
Project Status: Completed
URL for project: https://aihta.at/page/bewertung-medizinischer-einzelleistungen-mel-2023/en
Year Published: 2023
URL for published report: https://eprints.aihta.at/1455/1/DSD_136.pdf
URL for additional information: https://eprints.aihta.at/1455/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Essential Tremor
  • Ultrasonic Therapy
  • Magnetic Resonance Imaging, Interventional
  • Ultrasonography, Interventional
  • Magnetic Resonance Imaging
  • High-Intensity Focused Ultrasound Ablation
Keywords
  • Transcranial magnetic resonance-guided high-intensity focused ultrasound treatment
  • focused ultrasound thalamotomy
  • drug-resistant essential tremor
Contact
Organisation Name: Austrian Institute for Health Technology Assessment
Contact Address: Garnisongasse 7/20, A-1090 Vienna, Austria
Contact Name: office@aihta.at
Contact Email: office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.