Authors' objectives: To determine whether there is any evidence on the efficacy and/or effectiveness of (oral) collagen supplements in treating patients diagnosed with shoulder sprain/strains.

Authors' results and conclusions: Overall, there were 97 published studies identified in this systematic review. Upon examination of the titles and abstracts of these 97 published studies, none were thought to be relevant for the objective of this systematic review. However, it seems that oral collagen supplementation may not be completely safe. A case report (level of evidence 4. Appendix 1) on severe adverse cutaneous drug eruptions (Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis) induced by the consumption of collagen supplements was reported in a healthy 30-year-old woman, with no history of allergy to food or medications. It was reported in the literature that she had been consuming marine based collagen (main sources of commercial collagen are marine, porcine, and bovine) for 1 month. At present, there is no published study supporting (or refuting) the efficacy and/or effectiveness of collagen supplementation in treating (either as a stand-alone or partial treatment) on patients diagnosed with (shoulder) sprain/strain or those with musculoskeletal problems. At present, there is some evidence (in the form of a case report) on the potential for adverse events associated with the consumption of oral collagen as a health supplement.

Authors' recommendations: Overall, there were 97 published studies identified in this systematic review. Upon examination of the titles and abstracts of these 97 published studies, none were thought to be relevant for the objective of this systematic review. However, it seems that oral collagen supplementation may not be completely safe. A case report (level of evidence 4. Appendix 1) on severe adverse cutaneous drug eruptions (Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis) induced by the consumption of collagen supplements was reported in a healthy 30-year-old woman, with no history of allergy to food or medications. It was reported in the literature that she had been consuming marine based collagen (main sources of commercial collagen are marine, porcine, and bovine) for 1 month. At present, there is no published study supporting (or refuting) the efficacy and/or effectiveness of collagen supplementation in treating (either as a stand-alone or partial treatment) on patients diagnosed with (shoulder) sprain/strain or those with musculoskeletal problems. At present, there is some evidence (in the form of a case report) on the potential for adverse events associated with the consumption of oral collagen as a health supplement.

Authors' methods: A comprehensive and systematic literature search was conducted on commercial medical literature databases on December 14, 2022. No limitations, such as on the language or date of publication, were implemented in any of these searches. A manual search on the references of the articles that were retrieved in full was also conducted.

Project Status: Completed

URL for project: https://www.worksafebc.com/en/about-us/research-services/evidence-based-medicine-and-systematic-reviews

Year Published: 2022

URL for published report: https://www.worksafebc.com/en/resources/health-care-providers/guides/oral-collagen-supplements-shoulder-sprain-strain?lang=en

English language abstract: An English language summary is available

Publication Type: Mini HTA

Country: Canada

Organisation Name: WorkSafeBC

Contact Address: 6591 Westminster Highway, Richmond, BC, V7C 1C6 Canada. Tel: 604-231-8417; Fax: 604-279-7698

Contact Name: ebpg@worksafebc.com

Contact Email: ebpg@worksafebc.com

Copyright: WorkSafe BC