Motivational support intervention to reduce smoking and increase physical activity in smokers not ready to quit: the TARS RCT

Taylor A H, Thompson T P, Streeter A, Chynoweth J, Snowsill T, Ingram W, Ussher M, Aveyard P, Murray RL, Harris T, Green C, Horrell J, Callaghan L, Greaves CJ, Price L, Cartwright L, Wilks J, Campbell S, Preece D, Creanor S
Record ID 32018004468
English
Authors' objectives: Physical activity can support smoking cessation for smokers wanting to quit, but there have been no studies on supporting smokers wanting only to reduce. More broadly, the effect of motivational support for such smokers is unclear. The objectives were to determine if motivational support to increase physical activity and reduce smoking for smokers not wanting to immediately quit helps reduce smoking and increase abstinence and physical activity, and to determine if this intervention is cost-effective. Behavioural support to aid smoking cessation is an effective and cost-effective intervention for smokers wanting to quit. Motivational support can reduce smoking, with greater reductions leading to successful quitting, but the evidence is fairly weak for those not wanting to immediately quit. Smoking reduction studies may involve two types of smokers: (1) those who want to quit and are willing to reduce first rather than quit abruptly and (2) those who do not want to quit (immediately) but are interested in smoking reduction or harm reduction. At least four studies have investigated the effects of behavioural support for smokers wanting to reduce but not quit, and provide imprecise or no evidence of effects on smoking reduction, quitting and sustained abstinence. Exercise has been shown to aid smoking cessation for those wanting to quit, but there is only exploratory evidence that promoting physical activity (PA) and supporting smoking reduction can facilitate smoking reduction and quitting. A definitive study is needed to determine the effectiveness and cost-effectiveness of behavioural support for smoking reduction and increasing PA, on smoking outcomes, especially prolonged, carbon monoxide-verified smoking abstinence. The overall aim of the Trial of physical Activity-assisted Reduction of Smoking (TARS) was to determine if adding a motivational intervention to reduce smoking and increase PA to usual support was more effective and cost-effective in facilitating carbon monoxide-verified 6-month floating prolonged abstinence. The specific research questions were as follows. Compared with usual support, did the TARS intervention: increase the proportion of participants achieving carbon monoxide-verified 6-month floating prolonged abstinence at 9 months post baseline? increase the proportion of participants reporting a ≥ 50% reduction in the number of cigarettes smoked (between baseline and 3 months, and baseline and 9 months)? increase the proportion of participants achieving carbon monoxide-verified 12-month floating prolonged abstinence at 15 months post baseline? increase the proportion of participants achieving self-reported and carbon monoxide-verified point prevalence abstinence at 3 and 9 months post baseline? increase self-reported PA at 3 and 9 months post baseline, and accelerometer-assessed PA at 3 months post baseline? improve body mass index, quality of life, sleep, cigarette cravings and other beliefs about smoking and PA at 3 and 9 months post baseline? What were the intervention, health-care and social care costs, compared with support as usual, at 9 months post baseline? Was the intervention cost-effective, compared with usual support, (1) at 9 months, and (2) over a longer-term/lifetime horizon? Were the trial methods and intervention acceptable and feasible, based on an embedded internal pilot phase? Did the intervention demonstrate good fidelity (design, training, delivery, receipt and enactment) and acceptability and what were the mechanisms of action of the intervention?
Authors' results and conclusions: The average age of the sample was 49.8 years, and participants were predominantly from areas with socioeconomic deprivation and were moderately heavy smokers. The intervention was delivered with good fidelity. Few participants achieved carbon monoxide-verified 6-month prolonged abstinence [nine (2.0%) in the intervention group and four (0.9%) in the control group; adjusted odds ratio 2.30 (95% confidence interval 0.70 to 7.56)] or 12-month prolonged abstinence [six (1.3%) in the intervention group and one (0.2%) in the control group; adjusted odds ratio 6.33 (95% confidence interval 0.76 to 53.10)]. At 3 months, the intervention participants smoked fewer cigarettes than the control participants (21.1 vs. 26.8 per day). Intervention participants were more likely to reduce cigarettes by ≥ 50% by 3 months [18.9% vs. 10.5%; adjusted odds ratio 1.98 (95% confidence interval 1.35 to 2.90] and 9 months [14.4% vs. 10.0%; adjusted odds ratio 1.52 (95% confidence interval 1.01 to 2.29)], and reported more moderate-to-vigorous physical activity at 3 months [adjusted weekly mean difference of 81.61 minutes (95% confidence interval 28.75 to 134.47 minutes)], but not at 9 months. Increased physical activity did not mediate intervention effects on smoking. The intervention positively influenced most smoking and physical activity beliefs, with some intervention effects mediating changes in smoking and physical activity outcomes. The average intervention cost was estimated to be £239.18 per person, with an overall additional cost of £173.50 (95% confidence interval −£353.82 to £513.77) when considering intervention and health-care costs. The 1.1% absolute between-group difference in carbon monoxide-verified 6-month prolonged abstinence provided a small gain in lifetime quality-adjusted life-years (0.006), and a minimal saving in lifetime health-care costs (net saving £236). There was no evidence that behavioural support for smoking reduction and increased physical activity led to meaningful increases in prolonged abstinence among smokers with no immediate plans to quit smoking. The intervention is not cost-effective. The sample (n = 915) had a mean age of 49.8 [standard deviation (SD) 13.9] years; 55% were female and 85% identified as white. Sixty per cent lived within one of the four highest-ranked deciles for social deprivation. They initially smoked an average of 18.0 cigarettes daily, with 77.68% smoking within 30 minutes of waking, and reported doing a median of 337 minutes of moderate to vigorous physical activity (MVPA) weekly. Primary analysis Using the Russell Standard, assuming missing participant data at follow-up implied continued smoking, 0.9% (n = 4) of control and 2.0% (n = 9) of intervention participants achieved carbon monoxide-verified 6-month floating prolonged abstinence between 3 and 9 months. This difference was not statistically significant [fully adjusted estimated odds ratio 2.30, 95% confidence interval (CI) 0.70 to 7.56; p = 0.169]. Including participants who achieved the outcome between 9 and 15 months increased this to 2.2% (n = 10) and 3.1% (n = 14) in the control and intervention groups, respectively, which was also not statistically significantly different (fully adjusted estimated odds ratio 1.43, 95% CI 0.62 to 3.26; p = 0.398). For the 19 and 20 participants followed up at 15 months, 0.2% (n = 1) and 1.3% (n = 6) of the overall control and intervention groups, respectively, achieved carbon monoxide-verified 12-month floating prolonged abstinence, which was also not statistically significantly different (fully adjusted estimated odds ratio 6.3, 95% CI 0.8 to 53.1; p = 0.089). There was no evidence that the intervention increased the likelihood of achieving carbon monoxide-verified prolonged abstinence from smoking, although it did lead to short-term increases in PA and abstinence, and ≥ 50% reductions in the number of cigarettes smoked per day at up to 3 and 9 months. The intervention was delivered with good fidelity, and process measures appeared to mediate short-term, but not longer-term, changes in the number of cigarettes smoked daily and PA. Overall, participants found the intervention acceptable. The intervention is not cost-effective by UK standards. The trial shows that it is possible to engage heavier smokers, many living in areas with high social deprivation, in a smoking reduction and PA intervention, with some positive effects on both behaviours. But further adaptations would be needed to translate early behaviour change into quit attempts and prolonged abstinence, and longer-term PA improvements.
Authors' recommendations: The average age of the sample was 49.8 years, and participants were predominantly from areas with socioeconomic deprivation and were moderately heavy smokers. The intervention was delivered with good fidelity. Few participants achieved carbon monoxide-verified 6-month prolonged abstinence [nine (2.0%) in the intervention group and four (0.9%) in the control group; adjusted odds ratio 2.30 (95% confidence interval 0.70 to 7.56)] or 12-month prolonged abstinence [six (1.3%) in the intervention group and one (0.2%) in the control group; adjusted odds ratio 6.33 (95% confidence interval 0.76 to 53.10)]. At 3 months, the intervention participants smoked fewer cigarettes than the control participants (21.1 vs. 26.8 per day). Intervention participants were more likely to reduce cigarettes by ≥ 50% by 3 months [18.9% vs. 10.5%; adjusted odds ratio 1.98 (95% confidence interval 1.35 to 2.90] and 9 months [14.4% vs. 10.0%; adjusted odds ratio 1.52 (95% confidence interval 1.01 to 2.29)], and reported more moderate-to-vigorous physical activity at 3 months [adjusted weekly mean difference of 81.61 minutes (95% confidence interval 28.75 to 134.47 minutes)], but not at 9 months. Increased physical activity did not mediate intervention effects on smoking. The intervention positively influenced most smoking and physical activity beliefs, with some intervention effects mediating changes in smoking and physical activity outcomes. The average intervention cost was estimated to be £239.18 per person, with an overall additional cost of £173.50 (95% confidence interval −£353.82 to £513.77) when considering intervention and health-care costs. The 1.1% absolute between-group difference in carbon monoxide-verified 6-month prolonged abstinence provided a small gain in lifetime quality-adjusted life-years (0.006), and a minimal saving in lifetime health-care costs (net saving £236). There was no evidence that behavioural support for smoking reduction and increased physical activity led to meaningful increases in prolonged abstinence among smokers with no immediate plans to quit smoking. The intervention is not cost-effective. The sample (n = 915) had a mean age of 49.8 [standard deviation (SD) 13.9] years; 55% were female and 85% identified as white. Sixty per cent lived within one of the four highest-ranked deciles for social deprivation. They initially smoked an average of 18.0 cigarettes daily, with 77.68% smoking within 30 minutes of waking, and reported doing a median of 337 minutes of moderate to vigorous physical activity (MVPA) weekly. Primary analysis Using the Russell Standard, assuming missing participant data at follow-up implied continued smoking, 0.9% (n = 4) of control and 2.0% (n = 9) of intervention participants achieved carbon monoxide-verified 6-month floating prolonged abstinence between 3 and 9 months. This difference was not statistically significant [fully adjusted estimated odds ratio 2.30, 95% confidence interval (CI) 0.70 to 7.56; p = 0.169]. Including participants who achieved the outcome between 9 and 15 months increased this to 2.2% (n = 10) and 3.1% (n = 14) in the control and intervention groups, respectively, which was also not statistically significantly different (fully adjusted estimated odds ratio 1.43, 95% CI 0.62 to 3.26; p = 0.398). For the 19 and 20 participants followed up at 15 months, 0.2% (n = 1) and 1.3% (n = 6) of the overall control and intervention groups, respectively, achieved carbon monoxide-verified 12-month floating prolonged abstinence, which was also not statistically significantly different (fully adjusted estimated odds ratio 6.3, 95% CI 0.8 to 53.1; p = 0.089). There was no evidence that the intervention increased the likelihood of achieving carbon monoxide-verified prolonged abstinence from smoking, although it did lead to short-term increases in PA and abstinence, and ≥ 50% reductions in the number of cigarettes smoked per day at up to 3 and 9 months. The intervention was delivered with good fidelity, and process measures appeared to mediate short-term, but not longer-term, changes in the number of cigarettes smoked daily and PA. Overall, participants found the intervention acceptable. The intervention is not cost-effective by UK standards. The trial shows that it is possible to engage heavier smokers, many living in areas with high social deprivation, in a smoking reduction and PA intervention, with some positive effects on both behaviours. But further adaptations would be needed to translate early behaviour change into quit attempts and prolonged abstinence, and longer-term PA improvements.
Authors' methods: This was a multicentred, two-arm, parallel-group, randomised (1 : 1) controlled superiority trial with accompanying trial-based and model-based economic evaluations, and a process evaluation. Participants from health and other community settings in four English cities received either the intervention (n = 457) or usual support (n = 458). The main outcome measures were carbon monoxide-verified 6- and 12-month floating prolonged abstinence (primary outcome), self-reported number of cigarettes smoked per day, number of quit attempts and carbon monoxide-verified abstinence at 3 and 9 months. Furthermore, self-reported (3 and 9 months) and accelerometer-recorded (3 months) physical activity data were gathered. Process items, intervention costs and cost-effectiveness were also assessed. Prolonged abstinence rates were much lower than expected, meaning that the trial was underpowered to provide confidence that the intervention doubled prolonged abstinence. The study involved a multicentred, parallel, two-group, individually randomised controlled, superiority trial with a mixed-methods embedded process evaluation and economic evaluations. Recruitment took place over 16 months from January 2018, with follow-up assessments ending in October 2020 (with only minimal overlap with COVID-19 restrictions) around four English cities: Plymouth, Nottingham, London and Oxford. Intervention participants were offered up to eight face-to-face or telephone behavioural support sessions to reduce smoking and increase PA, with up to six additional sessions if a participant wanted support with cessation. Substantial patient and public involvement supported both the development and evaluation of a pilot trial of the intervention, and adaptations for the present intervention. An intervention manual underpinned the training and remote supervision of eight health trainers (HTs) across four sites, and all aspects of intervention fidelity (design, training, receipt, delivery and enactment) were assessed. The client-centred intervention was informed by motivational interviewing and linked to self-determination theory. It aimed to empower participants to decide what support they required, and where, when and for how long, and, if the participant became ready to quit, to provide appropriate support. Control participants received brief advice on smoking cessation. Participants were recruited from primary and secondary care and community settings. Participants were adult smokers (≥ 18 years) who smoked ≥ 10 cigarettes per day (for at least 1 year), who wanted to reduce smoking but not quit immediately. Smokers were ineligible if they were unable to engage in at least 15 minutes of moderate-intensity PA, had any illness or injury that might be exacerbated by exercise, or were unable to engage in the trial and/or the intervention because of a language barrier or for other reasons. Following screening and consent, participants completed baseline assessments face to face or via telephone. At 3 and 9 months post baseline, participants were posted a questionnaire (and an accelerometer at 3 months for a random sample). Participants reporting having made a quit attempt and not having smoked at follow-up were invited to complete a biochemical verification of abstinence. Most did this with a carbon monoxide expired air test, but a few were posted a saliva cotinine test kit late in the trial as a result of COVID-19 restrictions. Those with carbon monoxide-verified abstinence at 9 months were also followed up at 15 months. The primary outcome was carbon monoxide-verified 6-month floating prolonged (i.e. with no fixed quit date) abstinence between 3 and 9 months. Other smoking measures were carbon monoxide-verified 12-month floating prolonged abstinence, point prevalence self-reported abstinence and number of cigarettes smoked per day, and carbon monoxide-verified abstinence and number of quit attempts at both 3 and 9 months. Analyses of smoking abstinence outcomes were in line with the Russell Standard, with non-responders assumed to be still smoking. Self-reported (3 and 9 months) and accelerometer-recorded (3 months) PA, body mass index, sleep and quality of life were also assessed at 3 and 9 months. The embedded mixed-methods process evaluation was split into two phases: (1) an initial evaluation linked to the internal pilot phase and (2) the subsequent main trial phase, with four workstreams as follows – (1) data related to levels of intervention engagement; (2) assessment of intervention delivery, receipt and enactment fidelity, using survey items related to the intervention logic model and recorded intervention sessions; (3) mediation analyses of changes in PA and process measures on outcomes; and (4) an embedded qualitative study with HT and intervention participant interviews. The health economic evaluation included an estimation of the cost of delivering the intervention from data collected during the trial, supplemented by investigator estimates. A trial-based economic evaluation was conducted using patient-reported resource use and health-related quality of life (EuroQol-5 Dimensions, five-level version), collected in questionnaire booklets at baseline and at 3 and 9 months post randomisation. Aggregate costs and quality-adjusted life-years (QALYs) over a 9-month time horizon were estimated and regression methods were used to adjust for potential confounders. A decision-analytic model was developed following a review of the existing literature. Smoking cessation rates were assumed to affect rates of coronary obstructive pulmonary disease, coronary heart disease, stroke and lung cancer, as well as quality of life and other smoking-related causes of mortality. Lifetime costs and QALYs were estimated.
Details
Project Status: Completed
Year Published: 2023
URL for additional information: English
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: England, United Kingdom
MeSH Terms
  • Smoking Cessation
  • Smoking Cessation Agents
  • Cigarette Smoking
  • Smoking
  • Exercise
  • Exercise Therapy
  • Counseling
  • Health Behavior
  • Tobacco Use Disorder
  • Motivation
Keywords
  • SMOKING
  • REDUCTION
  • QUITTING
  • ABSTINENCE
  • PHYSICAL ACTIVITY
  • EXERCISE
  • ACCELEROMETER
  • ADULT
  • COST-BENEFIT ANALYSIS
  • BEHAVIOUR CHANGE
  • MOTIVATIONAL SUPPORT
  • MOTIVATIONAL INTERVIEWING
  • MEDIATION
  • PRIMARY HEALTH CARE
  • PROCESS EVALUATION
  • QUALITATIVE
  • QUALITY OF LIFE
  • QUALITY-ADJUSTED LIFE-YEARS
  • SELF-DETERMINATION THEORY
  • SELF-MONITORING
  • GOAL-SETTING
  • RCT
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.