[Stem cell therapy in selected orthopedic conditions]

Lazo E, Alfie V, Navarro E, Bardach A, Ciapponi A, García Martí S, Augustovski F, Alcaraz A, Pichon Riviere A
Record ID 32018004423
Original Title: Terapia de células madre en patología ortopédica seleccionada
Authors' recommendations: Low-quality evidence suggests that stem cell therapy in knee osteoarthritis versus placebo may result in a mild improvement of the joint function and pain, however, these effects do not extend beyond six months after treatment. In addition, low-quality evidence suggests that therapy with adipose tissue-derived mesenchymal stem cells in knee osteoarthritis versus other intra-articular treatments might result in a marginal improvement in joint function and pain, although these results do not maintain at long term. Low-quality evidence shows that bone marrow-derived mesenchymal stem cell therapy for knee osteoarthritis versus other treatments would not result in benefits in joint function and pain. Finally, very low-quality evidence does not allow to draw conclusions on the effectiveness and/or safety of stem cell therapy as treatment for tendinopathies The clinical practice guidelines and the coverage policies consulted do not recommend the use of stem cell therapy in the orthopedic conditions assessed in this report, due to the lack of evidence supporting its use. No economic evaluations related to the use of stem cell therapy in orthopedic pathologies have been found.
Project Status: Completed
Year Published: 2022
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Stem Cell Transplantation
  • Osteoarthritis, Knee
  • Tendinopathy
  • Mesenchymal Stem Cell Transplantation
  • Knee Injuries
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
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