The treatment of depression in primary care
NHS Centre for Reviews and Dissemination
Record ID 31995000033
To assess which treatments are effective in the management of depression in primary care.
Authors' results and conclusions: Clinical:Antidepressants are generally effective in the treatment of major depression but a significant number of patients drop out of treatment and many will relapse. The SSRI's are of similar efficacy to other antidepressants - standardised mean difference of 0.004 (95% CI -0.096 - 0.015). SSRI's also have similar drop out rates to the cheaper antidepressants - Odds Ratio = 0.9 (95% CI 0.86-1.07). Cognitive therapy has been shown to be as effective as usual treatment in primary care.
Authors' recomendations: Effective strategies to improve the detection and appropriateness of treatment of depression in primary care are available. The increasing use of the SSRI's as the routine first-line treatment in major depression may result in large increases in the NHS drug budget for antidepressants and should be carefully monitored. Further research is required to evaluate a variety of management strategies for depression.
Authors' methods: Systematic review
Project Status: Completed
URL for project: http://www.york.ac.uk/inst/crd/ehcb.htm
Year Published: 1993
English language abstract: An English language summary is available
Publication Type: Not Assigned
- Antidepressive Agents
- Serotonin Uptake Inhibitors
Organisation Name: University of York
Contact Address: University of York, York, Y01 5DD, United Kingdom. Tel: +44 1904 321040, Fax: +44 1904 321041,
Contact Name: firstname.lastname@example.org
Contact Email: email@example.com
Copyright: University of York
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