A rapid health technology assessment of gene expression profiling tests for guiding the use of adjuvant chemotherapy in early-stage invasive breast cancer

Health Information and Quality Authority
Record ID 32018004368
Authors' objectives: The aim of the rapid HTA is to provide advice to the HSE on alternatives to Oncotype DX® that may be used to inform decision-making in relation to the management of early-stage invasive breast cancer.
Authors' methods: The Terms of Reference of the rapid HTA were agreed between HIQA and the HSE NCCP. A multidisciplinary expert advisory group (EAG) was convened by HIQA comprising representation from relevant stakeholders. These included the HSE NCCP, clinicians with specialist expertise in medical oncology, breast cancer surgery and histopathology, representation from people affected by cancer, as well as representation from the Irish Cancer Society research department. A protocol for the systematic review of clinical effectiveness was agreed with the HSE NCCP and reviewed by the EAG. The clinical pathway for the screening, diagnosis and treatment of breast cancer in Ireland was described. The technical characteristics of the GEP tests, and international practice in relation to the use of GEP tests was described. The burden of disease associated with early breast cancer in Ireland was described. A systematic review was undertaken to review the clinical effectiveness of GEP tests. The draft report was reviewed by the Expert Advisory Group. A final draft report was submitted to the Board of HIQA for approval. Following its approval, the completed assessment was submitted to the HSE NCCP as advice.
Project Status: Completed
Year Published: 2023
Requestor: Health Service Executive
English language abstract: An English language summary is available
Publication Type: Mini HTA
Country: Ireland
MeSH Terms
  • Gene Expression Profiling
  • Breast Neoplasms
  • Biomarkers, Tumor
  • Chemotherapy, Adjuvant
  • Breast cancer
  • Gene expression profiling tests
  • GEP tests
  • Oncotype DX
Organisation Name: Health Information and Quality Authority (HIQA)
Contact Address: Health Information and Quality Authority, George's Court, George's Lane,Smithfield, Dublin 7. PH : + 353 (01) 814 7464
Contact Name: info@hiqa.ie
Contact Email: info@hiqa.ie
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.