Transcutaneous oxygen pressure monitoring (TcPO2)

Ros Aziah MR, Ku Nurhasni KAR, Izzuna MMG
Record ID 32018004255
Authors' objectives: To assess the effectiveness, cost-implication, safety and organisational issues related to the application of TcPO2
Authors' results and conclusions: A total of 559 records were identified through the Ovid interface and PubMed, and seven were identified from other sources (references of retrieved articles). After removal of 77 duplicates, 489 records were screened and 397 were excluded. Of these, 92 relevant abstracts were retrieved in full text. After reading, appraising, and applying the inclusion and exclusion criteria to the 92 full text articles, 12 full text articles were included and 80 full text articles were excluded. There was fair to good level of evidence retrieved to suggest that TcPO2 may predict wound healing, amputation and mortality among patients with diabetic foot ulcer, critical limb ischaemia and underlying peripheral arterial disease. However, there was no evidence that TcPO2 is suitable to substitute other modalities. The suggested threshold value for wound healing/tissue perfusion is >25 mmHg. No evidence retrieved on the safety.
Authors' recommendations: Based on the above review, TcPO2 may be used as an adjunct to current modalities for tissue perfusion and wound assessment. However, outcome data collection is encouraged.
Authors' methods: Electronic databases were searched through the Ovid interface: Ovid MEDLINE(R) ALL . EBM Reviews - Cochrane Central Register of Controlled Trials January 2022, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to January 23, 2022, EBM Reviews - Database of Abstracts of Reviews of Effects 1st Quarter 2016, EBM Reviews - Health Technology Assessment 4th Quarter 2016, EBM Reviews - NHS Economic Evaluation Database 1st Quarter 2016. Searches were also run in INAHTA database, PubMed database and U.S. Food and Drug Administration (USFDA) website. Google and Google Scholar were also used to search for additional web-based materials and information. Additional articles were identified from reviewing the references of retrieved articles. Last search was conducted on 28th January 2022.
Authors' identified further reserach: None
Project Status: Completed
Year Published: 2022
Requestor: Ministry of Health
English language abstract: An English language summary is available
Publication Type: Mini HTA
Country: Malaysia
MeSH Terms
  • Blood Gas Monitoring, Transcutaneous
  • Oxygen
  • Monitoring, Physiologic
  • Transcutaneous oxygen pressure
  • TcPO2
Organisation Name: Malaysian Health Technology Assessment
Contact Address: Malaysian Health Technology Assessment Section, Ministry of Health Malaysia, Federal Government Administrative Centre, Level 4, Block E1, Parcel E, 62590 Putrajaya Malaysia Tel: +603 8883 1229
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Copyright: Malaysian Health Technology Assessment Section (MaHTAS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.