[Tumour markers in certain cancer locations]

Garcia-Barcina M, Martin Bueno A E, Bujanda Fernandez de Pierola L, Julio Hernandez Hernandez J, Ortiz de Zarate Tercero A, Jose Suarez Torre M, Amezaga Asensio C, Loizate Totorikaguena A
Record ID 32003000144
Spanish
Original Title: Utilización de marcadores tumorales séricos en cáncer colo-rectal, carcinoma hepatocelular, cáncer de mama y cáncer de pulmón
Authors' objectives: The aim of this study is to analyse the scientific evidence of the value in the diagnosis and prognosis of CA19.9 and CEA in colorectal cancer, AFP in hepatocellular carcinoma, CA15.3, CEA y TPA in breast cancer and CA125, CEA, CYFRA21.1, NSE and SCC in lung cancer.
Authors' results and conclusions: 3,156 articles were localised and 464 were selected for the final analysis. The methodological value of the articles was not suitable, as most of them were retrospective clinical series. There was no tumor marker, among those analysed, that could be isolated as contributing to the diagnosis, prognosis or monitoring of the studied cancers.
Authors' recommendations: Data are insufficient to recommend: a) the use of CA19.9 or CEA in the screening, diagnosis, prognosis, surveillance or monitoring after treatment of patients with colorectal cancer; b) the use of AFP in the early detection of HCC; c) the use of CA15.3, CEA or TPA in the screening, diagnosis, staging, prognosis or follow-up after treatment of patients with breast cancer; d) the use of CA125, CEA, CYFRA21.1, NSE or SCC in the diagnosis, prognosis, early detection of recidive or monitoring of the response to treatment of patients with lung cancer.
Authors' methods: Systematic review of the literature and synthesis of the evidence. Steps: a) localization of previous practice guidelines or systematic reviews. b) Evaluation of this studies with the tables of critical lecture supplied by AGREE and OSTEBA. c) Computerized search on PubMed (until june 2001) and Cochrane Data Base (number 3-2000). The articles selected, according to the criteria assigned by group consensus, comprised articles in english, french, italian or spanish. d) levels of evidence and guideline grades were rated by the criteria of Canadian Medical Association (1979) and American Society of Clinical Oncology (ASCO). e) Analyse and synthesis of the data.
Details
Project Status: Completed
Year Published: 2002
URL for published report: https://www.euskadi.eus/contenidos/informacion/2002_osteba_publicacion/es_def/adjuntos/2002/d_02-03_marcadores_tumorales.pdf
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Spain
MeSH Terms
  • Biomarkers, Tumor
  • Neoplasms
Keywords
  • Colorectal Neoplasms
  • Hepatocellular Carcinoma
  • Breast Neoplasms
  • Lung Neoplasms
  • Gastrointestinal Neoplasms
  • alpha-Fetoproteins
  • CA-125 Antigen
  • Mucin-1
  • CA-19-9 Antigen
  • Carcinoembryonic Antigen
  • Tissue Polypeptide Antigen
  • Sensitivity and Specificity
Contact
Organisation Name: Basque Office for Health Technology Assessment
Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz
Contact Name: Lorea Galnares-Cordero
Contact Email: lgalnares@bioef.eus
Copyright: <p>Basque Office for Health Technology Assessment, Health Department Basque Government (OSTEBA)</p>
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