Guidance on the use of drugs for early thrombolysis in the treatment of acute myocardial infarction

National Institute for Clinical Excellence
Record ID 32003000010
Authors' objectives:

To provide guidance on the use of drugs for early thrombolysis in the treatment of acute myocardial infarction.

Authors' recommendations: Guidance: This guidance provides recommendations on the selection of thrombolytic drugs in patients with acute myocardial infarction (AMI). Recommendations are made in relation to the use of the drugs in hospital and pre-hospital settings. The guidance does not compare hospital and pre-hospital models of delivering thrombolysis. 1.1 It is recommended that, in hospital, the choice of thrombolytic drug (alteplase, reteplase, streptokinase or tenecteplase) should take account of: - the likely balance of benefit and harm (for example, stroke) to which each of the thrombolytic agents would expose the individual patient - current UK clinical practice, in which it is accepted that patients who have previously received streptokinase should not be treated with it again - the hospital's arrangements for reducing delays in the administration of thrombolysis. 1.2 Where pre-hospital delivery of thrombolytic drugs is considered a beneficial approach as part of an emergency-care pathway for AMI (for example, because of population geography or the accessibility of acute hospital facilities), the practicalities of administering thrombolytic drugs in pre-hospital settings mean that the bolus drugs (reteplase or tenecteplase) are recommended as the preferred option.
Authors' methods: Systematic review
Project Status: Completed
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Fibrinolytic Agents
  • Thrombolytic Therapy
  • Myocardial Infarction
Organisation Name: National Institute for Clinical Excellence
Contact Address: MidCity Place, 71 High Holborn, London WC1V 6NA, UK. Tel: +44 020 7067 5800; Fax: +44 020 7067 5801
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Copyright: National Institute for Clinical Excellence (NICE)
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